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Thiamine nitrate

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Identification
Molecular formula
C12H17N5O3S
CAS number
532-43-4
IUPAC name
2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol;nitrate
State
State

Thiamine nitrate is typically in a solid state at room temperature.

Melting point (Celsius)
196.00
Melting point (Kelvin)
469.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
327.36g/mol
Molar mass
327.3620g/mol
Density
1.3800g/cm3
Appearence

Thiamine nitrate appears as a white to off-white crystalline powder. It may also appear slightly yellowish.

Comment on solubility

Solubility of 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol; nitrate

The solubility of the compound 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol; nitrate can be influenced by various factors including its chemical structure and the presence of functional groups. Here are some insights:

  • Water Solubility: It is likely to be soluble in water due to the presence of the nitrate group and the hydrophilic ethanol moiety. These components tend to increase solubility in polar solvents.
  • Solvent Dependence: This compound may have different solubility profiles in various organic solvents, such as methanol, ethanol, or dimethyl sulfoxide (DMSO).
  • Temperature Effects: Higher temperatures often enhance solubility, which should be considered during experimental procedures.
  • pH Influence: The solubility may also be affected by the pH of the solution, especially because of the amino group, which may become protonated at lower pH levels.

In summary, while it is expected that this compound is generally soluble in polar solvents such as water, the exact solubility behavior should be experimentally determined based on the solvent and environmental conditions. Always perform solubility tests to ascertain the optimal conditions for use in chemical applications.

Interesting facts

Exploring 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol; nitrate

The compound 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol; nitrate is a fascinating entity within the realm of medicinal chemistry. Primarily studied for its potential pharmacological applications, it showcases several intriguing characteristics:

  • Chemical Complexity: The structural composition of this compound combines multiple heterocyclic rings, showcasing its complexity and versatility. The integration of pyrimidine and thiazole rings contributes to its biological activity.
  • Pharmaceutical Relevance: Compounds that contain both pyrimidine and thiazole moieties are often associated with a variety of therapeutic effects, including antibacterial and antiviral properties. Such compounds can act as potent inhibitors in different biological pathways.
  • Mechanisms of Action: It is commonly investigated for its ability to interfere with metabolic processes in pathogens, making it a candidate for drug development against infectious diseases.
  • Research in Progress: Ongoing research is focused on modifying different aspects of this compound to enhance its potency and selectivity. These modifications can lead to improved drug efficacy and reduced side effects.

As scientists continue to unravel the complexities of this compound, it is pivotal to note its structural variations could open new avenues for innovative therapies. In the words of one researcher, "Each small alteration could lead to significant breakthroughs in treatment options." This highlights the potential of 2-[3-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-3-ium-5-yl]ethanol; nitrate as a valuable tool in the pharmaceutical arsenal.

In conclusion, the exploration of this compound not only contributes to existing knowledge in the field of medicinal chemistry but also reflects the larger quest for novel therapeutic agents.

Synonyms
thiamine nitrate
532-43-4
THIAMINE MONONITRATE
Vitamin B1 nitrate
Aneurine nitrate
thiamin mononitrate
Vitamin B(sub 1) nitrate
Mononitrato de tiamina
Thiamine mononitrate [USP]
EINECS 208-537-4
Thiamini mononitras
Vitanon (TN)
DTXSID4038762
UNII-8K0I04919X
Vitamin b1 (as thiamine nitrate)
Thiamine nitrate (JP17)
8K0I04919X
Thiamine mononitrate (USP)
THIAMINE NITRATE [JAN]
DTXCID2018762
THIAMINE MONONITRATE [MI]
THIAMINE NITRATE [MART.]
THIAMINE MONONITRATE [FCC]
THIAMINE MONONITRATE [VANDF]
THIAMINE MONONITRATE [WHO-DD]
THIAMINE MONONITRATE [WHO-IP]
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium nitrate
3-(4-Amino-2-methylpyrimidyl-5-methyl)-4-methyl-5,beta-hydroxyethylthiazolium nitrate
THIAMINE NITRATE [EP IMPURITY]
3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium nitrate
THIAMINE NITRATE [EP MONOGRAPH]
THIAMINI MONONITRAS [WHO-IP LATIN]
THIAMINE MONONITRATE [USP MONOGRAPH]
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m-ethylthiazolium nitrate (salt)
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m-ethyl-, nitrate (salt)
THIAMINE NITRATE (MART.)
THIAMINE NITRATE (EP IMPURITY)
THIAMINE NITRATE (EP MONOGRAPH)
THIAMINE MONONITRATE (USP MONOGRAPH)
Vitanon
3-((4-amino-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium nitrate
Mononitrate, Thiamine
THIAMINE NITRATE [INCI]
3-(4-Amino-2-methylpyrimidin-5-ylmethyl)-5-(2-hydroxyethyl)-4-methylthiazolium nitrate
Vitamin B1 mononitrate
Aneurine mononitrate
Betabion mononitrate
Thiamine nitrate (salt)
MFCD00036330
2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethanol;nitrate
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, nitrate (salt)
Thiaminenitrate
Thiamine nitrate, 95%
Thiamine nitrate (Standard)
SCHEMBL60971
Thiamine nitrate, AldrichCPR
CHEMBL2104496
HY-B2223R
HY-B2223
Tox21_302321
AKOS015918391
AKOS015961239
AKOS040740936
CS-7673
FT31363
Thiamine mononitrate, >=98% (HPLC)
NCGC00255700-01
AC-13450
AS-15189
CAS-532-43-4
DA-68141
THIAMINE NITRATE (SALT) [WHO-IP]
Thiazolium,3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-,nitrate (salt)
NS00080123
T0182
D03277
E78994
Q7783874
Thiamine mononitrate, British Pharmacopoeia (BP) Reference Standard
Thiamine nitrate, European Pharmacopoeia (EP) Reference Standard
Thiamine Nitrate, Pharmaceutical Secondary Standard; Certified Reference Material
Thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-, nitrate (1:1)
Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2hydroxyethyl)-4-m-ethyl-, nitrate (salt)