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Clonidine

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Identification
Molecular formula
C9H9ClN2O
CAS number
4205-90-7
IUPAC name
2-[3-(4-chlorophenyl)-4-imino-2-oxo-imidazolidin-1-yl]acetonitrile
State
State

At room temperature, clonidine is generally found in a solid state as a powder or crystalline form, depending on its specific salt form.

Melting point (Celsius)
125.50
Melting point (Kelvin)
398.65
Boiling point (Celsius)
296.00
Boiling point (Kelvin)
569.15
General information
Molecular weight
231.65g/mol
Molar mass
231.6610g/mol
Density
1.1605g/cm3
Appearence

Clonidine hydrochloride appears as a white, odorless, crystalline substance. It is soluble in water and alcohol and slightly soluble in chloroform. The base form of clonidine may have a similar appearance but less water solubility compared to the hydrochloride form.

Comment on solubility

Solubility of 2-[3-(4-chlorophenyl)-4-imino-2-oxo-imidazolidin-1-yl]acetonitrile

The solubility of the compound 2-[3-(4-chlorophenyl)-4-imino-2-oxo-imidazolidin-1-yl]acetonitrile can be influenced by several factors, leading to distinct behaviors in various solvents. Understanding its solubility characteristics is essential for its applications and effectiveness in chemical processes.

Factors Influencing Solubility

  • Polarity: The polar characteristics of solvents such as water may lead to limited solubility for this compound due to its structural complexities and functional groups.
  • Hydrogen bonding: The presence of imino and oxo functional groups may allow for potential hydrogen bonding interactions, which can enhance solubility in polar solvents.
  • Temperature: Increased temperatures may improve solubility by providing more kinetic energy, overcoming lattice energy barriers.

General Observations

Typically, compounds with similar functional groups and molecular sizes demonstrate comparable solubility patterns. Thus, it is reasonable to hypothesize that:

  • The compound may exhibit low solubility in polar solvents while showing improved solubility in organic solvents.
  • If combined with the appropriate solvent or co-solvent system, solubility could be enhanced significantly.

In conclusion, while specific data may be necessary for precise solubility determinations, understanding the interplay of chemical structure, solvent properties, and environmental conditions remains vital in predicting the behavior of 2-[3-(4-chlorophenyl)-4-imino-2-oxo-imidazolidin-1-yl]acetonitrile in solution.

Interesting facts

Interesting Facts about 2-[3-(4-chlorophenyl)-4-imino-2-oxo-imidazolidin-1-yl]acetonitrile

This intriguing compound, often abbreviated as a part of pharmacologically active substances, exhibits noteworthy properties and potential applications. Here are some fascinating aspects to consider:

  • Pharmacological Potential: Compounds like this one are frequently explored for their medicinal abilities. By modulating biological systems, they can serve as precursors to a variety of drugs, particularly in treating diseases involving the central nervous system.
  • Imidazolidinone Structure: The imidazolidinone ring in this compound is significant. This unique structure is known to enhance the compound’s ability to interact with biological targets, which may lead to breakthroughs in drug design.
  • Chloro Substituent: The presence of the 4-chlorophenyl group is particularly noteworthy. Substituents like this one can contribute to the lipophilicity of the compound, influencing its absorption and distribution within biological systems.
  • Diverse Applications: Beyond pharmaceuticals, compounds of this nature can also find utility in materials science as well as in the formulation of agrochemicals.
  • Research and Development: As a scientist or a chemistry student, exploring compounds with complexity and structural versatility like this can lead to innovative research. Their synthesis and characterization often present engaging challenges.

In summary, 2-[3-(4-chlorophenyl)-4-imino-2-oxo-imidazolidin-1-yl]acetonitrile exemplifies the rich tapestry of chemical research where organic compounds can offer infinite possibilities. Each structural component plays a critical role in defining the compound’s behavior and potential, emphasizing the beauty of chemistry in unraveling the mysteries of molecular interactions.

Synonyms
NIMAZONE
17230-89-6
Nimazona
Nimazonum
Nimazone [USAN:INN]
Nimazone (USAN)
UNII-N71M372MP4
WIN 25,347
Win 25347
N71M372MP4
NIMAZONE [USAN]
NIMAZONE [INN]
WIN-25347
3-(p-Chlorophenyl)-4-imino-2-oxo-1-imidazolidineacetonitrile
1-Imidazolidineacetonitrile, 3-(4-chlorophenyl)-4-imino-2-oxo-
(3-(4-Chlorphenyl)-4-imino-2-oxo-1-imidazolidinyl)acetonitril
1-Imidazolidineacetonitrile, 3-(p-chlorophenyl)-4-imino-2-oxo-
2-[3-(4-chlorophenyl)-4-imino-2-oxoimidazolidin-1-yl]acetonitrile
2-(3-(4-Chlorophenyl)-4-imino-2-oxoimidazolidin-1-yl)acetonitrile
SCHEMBL43063
CHEMBL2104524
DTXSID70864752
CHEBI:229882
NS00122175
D05168
Q27284647
[3-(4-Chlorophenyl)-4-imino-2-oxoimidazolidin-1-yl]acetonitrile