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Clopenthixol

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Identification
Molecular formula
C20H23ClN2O2
CAS number
53716-50-0
IUPAC name
2-[3-(4-chlorophenyl)butyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline
State
State

At room temperature, Clopenthixol is in a solid state. It is typically handled as a powder when used in a laboratory or pharmaceutical context.

Melting point (Celsius)
104.00
Melting point (Kelvin)
377.15
Boiling point (Celsius)
503.30
Boiling point (Kelvin)
776.45
General information
Molecular weight
361.87g/mol
Molar mass
361.8700g/mol
Density
1.2600g/cm3
Appearence

Clopenthixol appears as a white to off-white crystalline powder. It does not have a distinctive color and is typically found in its pure form without any impurities that would significantly alter its appearance.

Comment on solubility

Solubility of 2-[3-(4-chlorophenyl)butyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline

The solubility of 2-[3-(4-chlorophenyl)butyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline in various solvents can be influenced by its structural characteristics. Here are some key points to consider:

  • Polarity: The presence of multiple methoxy groups likely increases the polar nature of this compound, potentially enhancing its solubility in polar solvents such as methanol or ethanol.
  • Hydrophobic regions: The bulky aromatic ring (4-chlorophenyl) and the butyl chain may contribute to increased hydrophobicity, making it less soluble in water. In this case, non-polar solvents like hexane or chloroform might be more effective.
  • pH Sensitivity: The solubility can vary significantly with changes in pH, which may affect the ionization state of the compound. A careful examination of the pKa values would yield insights into its solubility under different conditions.

In summary, the solubility of this compound is likely variable depending on the choice of solvent and conditions. It is essential to conduct empirical solubility tests to determine the most appropriate solvent for its applications. As noted in chemical literature, “Solubility is not merely a characteristic of a compound; it is influenced by a complex interplay of molecular structure and solvent properties.”

Interesting facts

Interesting Facts about 2-[3-(4-chlorophenyl)butyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline

The compound 2-[3-(4-chlorophenyl)butyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline is a fascinating member of the isoquinoline family, known for its diverse range of biological activities. Here are some intriguing insights about this compound:

  • Structural Characteristics: The compound features a complex structure with a fused isoquinoline ring system, which contributes to its unique chemical behavior and potential pharmacological properties.
  • Biological Significance: Isoquinolines are often studied for their medicinal properties, including their action as analgesics, anti-inflammatory agents, and potential antitumor compounds. This particular derivative may exhibit similar effects, making it a compound of interest in medicinal chemistry.
  • Substituent Effects: The presence of the 4-chlorophenyl group likely influences the compound's binding affinity and activity at biological targets. Substituents on aromatic rings can dramatically alter the biological properties of a compound.
  • Research Potential: Ongoing research into isoquinoline derivatives, including this compound, may uncover novel therapeutic agents for various diseases, particularly those associated with neurological disorders.
  • Synthesis Challenges: The synthesis of such complex compounds can be challenging, involving multiple steps and careful purification processes. Mastery of synthetic techniques is essential for chemists working in this field.

This compound exemplifies the intricate relationship between structure, function, and activity in the realm of organic and medicinal chemistry. As research continues, compounds like this may play a key role in the development of new treatments and therapies.

Synonyms
2-[3-(4-chlorophenyl)butyl]-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
AM-814/41092352
CHEMBL1907039