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Tetrahydropalmatine

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Identification
Molecular formula
C20H24ClNO2
CAS number
10097-84-4
IUPAC name
2-[3-(4-chlorophenyl)propyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline
State
State

This compound is typically present as a solid at room temperature.

Melting point (Celsius)
139.00
Melting point (Kelvin)
412.15
Boiling point (Celsius)
535.20
Boiling point (Kelvin)
808.35
General information
Molecular weight
337.87g/mol
Molar mass
337.8500g/mol
Density
1.0924g/cm3
Appearence

This compound typically appears as a crystalline powder. It can range in color from off-white to yellowish. The compound is often used in scientific and pharmaceutical applications.

Comment on solubility

Solubility of 2-[3-(4-chlorophenyl)propyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline

The solubility of the compound 2-[3-(4-chlorophenyl)propyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline can be influenced by several factors:

  • Polarity: This compound contains multiple methoxy groups, which can increase its polarity. Consequently, it may exhibit higher solubility in polar solvents such as water or alcohols.
  • Thermodynamic properties: The interaction between the solvent's molecules and the compound's structure will dictate solubility. Favorable enthalpic interactions can enhance solubility.
  • Temperature: Increasing the temperature generally increases solubility for most organic compounds. Thus, testing the compound at various temperatures can yield valuable insights.
  • pH Influence: For compounds containing nitrogen atoms, like this isoquinoline derivative, the pH can notably affect solubility, especially in acidic or basic conditions.

In summary, the solubility of this compound can be described as complex, depending on the interactions with various solvents, environmental conditions, and structural characteristics. Experimentation is often necessary to establish precise solubility limits for practical applications.

Interesting facts

Interesting Facts about 2-[3-(4-chlorophenyl)propyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline

This compound features a complex structure that intertwines various functional groups, showcasing the intriguing world of organic chemistry. As a member of the isoquinoline family, it presents some unique characteristics worth noting:

  • Structure and Variation: The presence of both methoxy groups and a chlorophenyl moiety allows for a diverse range of interactions, making it a versatile candidate for further chemical modifications.
  • Pharmacological Potential: Compounds like this one have been studied for their potential therapeutic applications. The isoquinoline framework is often associated with various biological activities, including antidepressant and antitumor properties.
  • Synthesis: The synthesis of this compound typically involves multi-step reactions that require careful control of conditions to achieve the desired structure. Chemists often explore different pathways to optimize yields.
  • Chirality: The compound features chiral centers, which may lead to different enantiomers with distinct biological activities. This highlights the importance of stereochemistry in drug design.
  • Research Significance: Compounds with such complex structures are often of significant interest in academic research, pushing the boundaries of our understanding of chemical reactivity and biological interaction.

Overall, 2-[3-(4-chlorophenyl)propyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline serves as a fascinating example of how intricate design in organic molecules can lead to promising avenues in medicinal chemistry.