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Iohexol

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Identification
Molecular formula
C19H26I3N3O9
CAS number
66108-95-0
IUPAC name
2-(3-acetamido-2,4,6-triiodo-phenoxy)-2-(4-iodophenyl)acetic acid
State
State

Iohexol is solid at room temperature, but it is commonly used in liquid form as an injectable solution.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.15
Boiling point (Celsius)
395.00
Boiling point (Kelvin)
668.15
General information
Molecular weight
821.15g/mol
Molar mass
821.1450g/mol
Density
2.3700g/cm3
Appearence

Iohexol appears as a white to off-white crystalline powder. It is often supplied in a sterile, aqueous solution for medical imaging purposes. These solutions are typically clear and colorless.

Comment on solubility

Solubility of 2-(3-acetamido-2,4,6-triiodo-phenoxy)-2-(4-iodophenyl)acetic acid

The solubility of 2-(3-acetamido-2,4,6-triiodo-phenoxy)-2-(4-iodophenyl)acetic acid is an intriguing aspect of this compound due to the presence of multiple halogen atoms and a phenyl group. Understanding its solubility can provide insights into its behavior in various chemical environments.

Key Factors Influencing Solubility:

  • Polar vs. Non-Polar Characteristics: The compound’s structure features significant polar functional groups, which often enhances solubility in polar solvents like water.
  • Hydrogen Bonding: The acetamido group may facilitate hydrogen bonding, potentially increasing solubility in aqueous environments.
  • Halogen Presence: The multiple iodine atoms may impart hydrophobic properties that can decrease solubility in certain organic solvents.
  • Molecular Weight: High molecular weight due to multiple aromatic rings and halogen substitutions may limit solubility further.

In summary, while one might expect some degree of solubility in polar solvents because of the acetamido group, the overall solubility of 2-(3-acetamido-2,4,6-triiodo-phenoxy)-2-(4-iodophenyl)acetic acid can be complex and likely influenced by the balance of hydrophilic and hydrophobic characteristics within its chemical structure.

Interesting facts

Interesting Facts about 2-(3-acetamido-2,4,6-triiodo-phenoxy)-2-(4-iodophenyl)acetic acid

This compound represents a fascinating intersection of medicinal chemistry and material sciences, particularly due to its unique structure and the presence of iodine atoms, which are known for their diverse applications in both fields. Here are some intriguing aspects:

  • Radioactive Properties: The incorporation of iodine into the structure provides potential for use in diagnostic imaging and targeted radiotherapy, especially in the field of oncology.
  • Pharmaceutical Applications: This compound may serve as a precursor or scaffold in the development of pharmaceuticals, particularly those targeting hormonal pathways and immune responses.
  • Environmental Impact: Compounds containing halogens such as iodine may also have environmental implications, highlighting the need for careful assessment of their ecological effects, especially if used in agricultural or industrial applications.
  • Synthetic Pathways: The synthesis of this compound can be complex and may involve multi-step organic transformations, emphasizing the creativity and problem-solving skills valuable in organic chemistry.
  • Structure-Activity Relationships: Understanding how the variations in the molecular structure affect biological activity can lead to more effective drugs, making compounds like this a focus of considerable research.

In conclusion, 2-(3-acetamido-2,4,6-triiodo-phenoxy)-2-(4-iodophenyl)acetic acid showcases the beauty of chemical design and the complexity of its potential uses in both health and environmental contexts. There's a significant emphasis on the need for responsible research and development to harness the full benefits of such compounds while mitigating risks.

Synonyms
23189-41-5
2-(3-Acetamido-2,4,6-triiodophenoxy)-2-(p-iodophenyl)acetic acid
Acido (4-iodofenil)(3-acetilamino-2,4,6-triiodofenossi)acetico [Italian]
Benzeneacetic acid, alpha-(3-(acetylamino)-2,4,6-triiodophenoxy)-4-iodo-
ACETIC ACID, 2-(3-ACETAMIDO-2,4,6-TRIIODOPHENOXY)-2-(p-IODOPHENYL)-
Acido (4-iodofenil)(3-acetilamino-2,4,6-triiodofenossi)acetico
RefChem:316452
Benzeneacetic acid, alpha-(3-(acetylamino)-2,4,6-triiodophenoxy)-4-iodo-(9CI)
2-(3-acetamido-2,4,6-triiodophenoxy)-2-(4-iodophenyl)acetic acid
DTXSID00945861
{3-[(1-Hydroxyethylidene)amino]-2,4,6-triiodophenoxy}(4-iodophenyl)acetic acid