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Iopamidol

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Identification
Molecular formula
C17H22I3N3O8
CAS number
60166-93-0
IUPAC name
2-[(3-acetamido-2,4,6-triiodo-phenyl)methyl]hexanedioic acid
State
State

Iopamidol is typically used in solution form for medical procedures as a contrast medium. As pure compound, it is a solid at room temperature. Due to its application, it is often encountered in a liquid form when dissolved for imaging techniques.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.15
Boiling point (Celsius)
245.00
Boiling point (Kelvin)
518.15
General information
Molecular weight
777.09g/mol
Molar mass
777.0900g/mol
Density
1.4690g/cm3
Appearence

Iopamidol is a white to off-white crystalline powder. It is often presented in a solution for medical use as a contrast agent. As a solid, it does not have any significant odor and can appear slightly hygroscopic in nature.

Comment on solubility

Solubility of 2-[(3-acetamido-2,4,6-triiodo-phenyl)methyl]hexanedioic acid

This compound, known as 2-[(3-acetamido-2,4,6-triiodo-phenyl)methyl]hexanedioic acid, exhibits interesting trends in solubility due to its unique structure and functional groups. Understanding its solubility characteristics is essential for applications in various fields such as pharmaceuticals and biochemistry.

Factors Influencing Solubility

Several factors affect the solubility of this compound:

  • Hydrophobic and Hydrophilic Portions: The presence of the triiodophenyl group contributes a significant hydrophobic character, while the acetamido and hexanedioic acid groups enhance hydrophilicity.
  • pH Dependence: The solubility may vary with pH, particularly due to the carboxylic acid functionality, which can ionize under basic conditions.
  • Temperature: Solubility is likely to increase with temperature; therefore, it is important to consider solubility testing at various temperatures for accurate assessments.

General Solubility Characteristics

While detailed solubility data may not be widely available, it can generally be stated that:

  • This compound is expected to be soluble in organic solvents such as dimethyl sulfoxide (DMSO) and acetone due to its hydrophobic regions.
  • Its solubility in water may be relatively limited but improved in acidic conditions where the carboxylic acid can remain protonated, enhancing interactions with water.

In conclusion, understanding the solubility of 2-[(3-acetamido-2,4,6-triiodo-phenyl)methyl]hexanedioic acid requires attention to its molecular structure and environmental conditions, which are critical for its practical applications.

Interesting facts

Interesting Facts about 2-[(3-acetamido-2,4,6-triiodo-phenyl)methyl]hexanedioic acid

This fascinating compound is a derivative of hexanedioic acid, featuring modifications that enhance its chemical profile and biological activity. Here are some noteworthy points:

  • Structural Complexity: The presence of a triiodinated phenyl group introduces significant electronic and steric effects, contributing to the compound's unique properties. The iodine atoms can greatly affect the reactivity and selectivity of the compound in chemical reactions.
  • Biological Relevance: Compounds with iodine substituents are often used in medicinal chemistry due to their ability to enhance bioavailability and therapeutic activity. The acetamido group adds an amide functionality, which can be crucial for biological interactions and binding affinity.
  • Applications: This compound may find applications in pharmaceuticals, particularly as a potential drug candidate for various diseases, owing to the role of iodine in enhancing the imaging properties of compounds in diagnostic methods.
  • Synthesis Insight: The synthetic routes to manufacture such complex molecules usually involve multiple steps, including functional group transformations and protection-deprotection strategies, showcasing the ingenuity of synthetic chemists.
  • Property Manipulation: The incorporation of multiple functional groups allows for tuning the characteristics of the compound, such as solubility and reactivity, making it a subject of great interest for research and development.

Understanding and exploring this compound not only unveils its individual characteristics but also opens pathways to innovative applications in various fields including chemistry, pharmacology, and material science. As the field of medicinal chemistry evolves, compounds like 2-[(3-acetamido-2,4,6-triiodo-phenyl)methyl]hexanedioic acid will undoubtedly contribute significantly to future discoveries.

Synonyms
BRN 3040151
2-(3-Acetamido-2,4,6-triiodobenzyl)adipic acid
Hexanedioic acid, 2-(3-acetamido-2,4,6-triiodobenzyl)-
10590-22-4
ADIPIC ACID, 2-(3-ACETAMIDO-2,4,6-TRIIODOBENZYL)-
Acido 2-(3-acetilamino-2,4,6-triiodobenzil)adipico [Italian]
Acido 2-(3-acetilamino-2,4,6-triiodobenzil)adipico
DTXSID10909818
2-({3-[(1-Hydroxyethylidene)amino]-2,4,6-triiodophenyl}methyl)hexanedioic acid