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Diltiazem

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Identification
Molecular formula
C22H26N2O4S
CAS number
42399-41-7
IUPAC name
2-[3-acetoxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]ethyl-dimethyl-ammonium
State
State

At room temperature, Diltiazem is found as a solid, specifically in a crystalline state.

Melting point (Celsius)
209.00
Melting point (Kelvin)
482.15
Boiling point (Celsius)
308.00
Boiling point (Kelvin)
581.15
General information
Molecular weight
414.55g/mol
Molar mass
414.5460g/mol
Density
1.3000g/cm3
Appearence

Diltiazem is typically a white to off-white crystalline powder that is odorless. It is highly soluble in water, soluble in alcohol, and practically insoluble in hydrocarbons.

Comment on solubility

Solubility of 2-[3-acetoxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]ethyl-dimethyl-ammonium

The solubility of the compound 2-[3-acetoxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]ethyl-dimethyl-ammonium, which has the chemical formula C22H26N2O4S, can be influenced by a variety of factors. Generally, compounds with ionic structures tend to exhibit higher solubility in polar solvents, while non-polar compounds dissolve well in non-polar solvents.

Here are some key points to consider regarding its solubility:

  • Polarity: Due to the presence of both an amine group and multiple aromatic systems, this compound may exhibit significant polarity, which could enhance its solubility in water and other polar solvents.
  • Hydrophobic and Hydrophilic Balance: The acetoxy and methoxy groups introduce varying degrees of hydrophobicity and hydrophilicity, suggesting a possibility for moderate to high solubility in organic solvents.
  • pH Influence: The solubility might also change with pH, as protonation of the amine group under acidic conditions could lead to increased solubility in polar mediums.

In summary, while specific solubility data is needed for precise applications, it is likely that the compound shows varied solubility profiles depending on the solvent environment, which is essential for its use in biological and chemical applications. As one quote emphasizes, "A substance’s behavior in solution speaks volumes about its potential applications." Therefore, understanding the solubility dynamics is crucial.

Interesting facts

Interesting Facts about 2-[3-acetoxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]ethyl-dimethyl-ammonium

The compound 2-[3-acetoxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]ethyl-dimethyl-ammonium is a fascinating molecule with intriguing properties and potential applications. Here are some interesting facts about this chemical compound:

  • Structure Complexity: This compound features a complex structure that incorporates both a benzothiazepine framework and an ammonium group, making it a versatile molecule in medicinal chemistry.
  • Therapeutic Potential: Compounds similar to this class are often explored for their pharmacological properties. Research has indicated possible applications in treating various conditions, particularly in areas like cardiovascular health and neurological disorders.
  • Functional Groups: The presence of multiple functional groups, such as acetoxy and methoxy, allows for extensive chemical reactivity and versatility in synthetic applications. These modifications can enhance the compound's biological activity.
  • Solubility and Stability: The dimethylammonium component may confer better solubility characteristics compared to other related compounds, enhancing its utility in pharmaceutical formulations.
  • Research Opportunities: This compound serves as an exciting lead structure for the development of new drugs and can be further modified to explore even more effective derivatives through structure-activity relationship (SAR) studies.
  • Synthesis Challenges: The synthesis of such complex molecules often requires sophisticated multi-step synthetic routes, making it both a challenge and an exciting task for chemists.

Overall, 2-[3-acetoxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]ethyl-dimethyl-ammonium exemplifies the rich intersection of chemistry and pharmacology, inspiring ongoing research and discovery in the field.