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Iopamidol

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Identification
Molecular formula
C17H22I3N3O8
CAS number
60166-93-0
IUPAC name
2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]-2-(m-tolyl)acetic acid
State
State

At room temperature, Iopamidol is typically available as a sterile, aqueous solution for intravenous injection, thus presenting as a liquid in common use cases. In its pure form, it exists as a crystalline solid.

Melting point (Celsius)
276.00
Melting point (Kelvin)
549.15
Boiling point (Celsius)
484.30
Boiling point (Kelvin)
757.45
General information
Molecular weight
777.09g/mol
Molar mass
777.0880g/mol
Density
2.0480g/cm3
Appearence

Iopamidol is a white or slightly yellow crystalline powder. It is odorless and typically formulated in aqueous solutions for clinical use. The crystalline nature can be observed under suitable microscopy.

Comment on solubility

Solubility of 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]-2-(m-tolyl)acetic acid

Understanding the solubility of this compound is crucial due to its complex structure. The solubility can often be influenced by several factors, including:

  • Polarity: The presence of polar functional groups, such as the acetyl and amino groups, suggests that this compound may have reasonable solubility in polar solvents.
  • Iodine Atoms: The triiodo component can impart some degree of hydrophobicity, thereby affecting its overall solubility profile.
  • pH Dependency: Being an acid, its solubility may change with the pH of the solution. The ionization state of the carboxylic acid group could lead to increased solubility in basic conditions.

In general, compounds like this one can be categorized based on their solubility characteristics:

  1. Highly soluble: If it readily dissolves in water or organic solvents.
  2. Moderately soluble: If it demonstrates limited solubility, requiring higher concentrations or specific conditions.
  3. Insoluble: If it does not dissolve significantly at all.

Overall, as with many organic compounds, understanding the solubility of 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]-2-(m-tolyl)acetic acid necessitates a consideration of both its structural features and the nature of the solvent used. Always remember, "like dissolves like," which is a key principle to keep in mind when predicting solubility behavior.

Interesting facts

Interesting Facts about 2-[3-[Acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]-2-(m-tolyl)acetic Acid

This fascinating compound, often referred to in the realm of medicinal chemistry, exhibits intriguing properties and potential applications. Here are some notable aspects:

  • Origin of Components: The compound features a unique combination of functional groups, including an acetylamino and a phenoxy moiety, which may contribute to its biological activity.
  • Iodo Substitution: The presence of three iodine atoms in its structure can significantly enhance the compound's radiopacity, making it conceivable for use in imaging applications such as X-ray contrast agents.
  • Synthesis Potential: The intricate structure of this compound opens up avenues for synthetic chemists to explore various pathways, including metal-catalyzed reactions or functionalization techniques.
  • Biological Activity: Compounds with a similar core structure have been studied for their potential capacity as pharmaceuticals, particularly in the fields of oncology and infectious diseases. The unique structural features may allow for tailored biological interactions.
  • Impact on Drug Design: As part of a broader class of compounds, this molecule could serve as a lead in structure-activity relationship (SAR) studies, aiding in the design of more effective therapeutics with reduced side effects.

The compound also sparks curiosity regarding its potential interactions and mechanisms of action. As we delve deeper into the world of such compounds, it's essential to consider how advancements in analytical techniques can help elucidate their complex behaviors in biological systems. As noted by many researchers in the field: "Understanding the intricacies of chemical interactions paves the way for groundbreaking discoveries."

This compound exemplifies the blend of synthetic strategy and biological significance, marking its place within the ongoing narrative of chemical research and drug development. Its study could unlock new therapeutic avenues while illustrating the beauty and complexity of chemical science.

Synonyms
BRN 2917037
23189-46-0
2-(3-(N-Ethylacetamido)-2,4,6-triiodophenoxy)-2-(m-tolyl)acetic acid
Acido (3-metilfenil)(3-N-etilacetilamino-2,4,6-triiodofenossi)acetico [Italian]
Benzeneacetic acid, alpha-(3-(acetylethylamino)-2,4,6-triiodophenoxy)-3-methyl-
ACETIC ACID, 2-(3-(N-ETHYLACETAMIDO)-2,4,6-TRIIODOPHENOXY)-2-(m-TOLYL)-
Acido (3-metilfenil)(3-N-etilacetilamino-2,4,6-triiodofenossi)acetico
RefChem:316436
Benzeneacetic acid, alpha-(3-(acetylethylamino)-2,4,6-triiodophenoxy)-3-methyl-(9CI)
DTXSID00945866
{3-[acetyl(ethyl)amino]-2,4,6-triiodophenoxy}(3-methylphenyl)acetic acid