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Iopamidol

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Identification
Molecular formula
C17H22I3N3O8
CAS number
60166-93-0
IUPAC name
2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]-2-(p-tolyl)acetic acid
State
State

At room temperature, Iopamidol is a solid, specifically in the form of a crystalline powder.

Melting point (Celsius)
210.00
Melting point (Kelvin)
483.15
Boiling point (Celsius)
100.00
Boiling point (Kelvin)
373.15
General information
Molecular weight
777.09g/mol
Molar mass
777.0880g/mol
Density
2.2820g/cm3
Appearence

Iopamidol appears as a white to off-white crystalline powder. It is generally odorless and slightly hygroscopic.

Comment on solubility

Solubility of 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]-2-(p-tolyl)acetic acid

The solubility of 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]-2-(p-tolyl)acetic acid can be a complex topic due to its intricate structural features. Generally, the **solubility** of this compound may be influenced by several key factors:

  • Polarity: The presence of functional groups such as the acetyl and amino groups can increase **polarity**, potentially enhancing solubility in polar solvents like water.
  • Hydrophobicity: The aromatic rings and the p-tolyl group contribute to the compound's hydrophobic characteristics, which can hinder solubility in polar solvents.
  • Temperature: As with many organic compounds, solubility may vary with temperature, often increasing at elevated temperatures.
  • pH Levels: Changes in pH can affect the protonation state of the amino group, influencing solubility; for instance, a more acidic environment may facilitate increased solubility by converting the amine to a more soluble quaternary ammonium salt.

Due to these factors, it’s important to consider that the solubility behavior of this compound might showcase variable characteristics depending on the conditions. As noted, the interaction between hydrophobic and hydrophilic elements of the structure plays a significant role in defining its overall solubility. Understanding these intricate relations can help in predicting how the compound will behave in various solvent systems.

Interesting facts

Interesting Facts about 2-[3-[Acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]-2-(p-tolyl)acetic Acid

This complex compound is a fascinating example of organic chemistry due to its unique structural features and significant applications in various fields. Here are some key points to consider:

  • Functional Groups: The compound contains multiple functional groups, including an amide and a carboxylic acid, which contribute to its reactivity and therapeutic potential.
  • Halogenation: The presence of three iodine atoms on the aromatic ring imparts unique properties to the compound. Halogenation often enhances the compound's biological activity and can impact its interaction with biological systems.
  • Therapeutic Applications: Due to its complex structure, this compound may display interesting biological activities. Compounds with similar functional groups are often explored for their pharmacological properties, which could include anti-inflammatory or antimicrobial effects.
  • Structure-Activity Relationship: The intricate interactions among the substituted groups in this compound make it a valuable subject for studying the structure-activity relationships in drug design. Such studies can provide insights into how slight modifications can lead to significant changes in activity.
  • Importance of Iodine: Iodine has been shown to play an important role in medicinal chemistry, especially when it comes to improving the efficacy and imaging capabilities of radiopharmaceuticals due to its radioactive isotopes.

In summary, the compound 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]-2-(p-tolyl)acetic acid embodies the intricate interplay of structure, reactivity, and potential biological activity that characterizes much of organic chemistry. Such compounds not only enhance our understanding of molecular interactions but also pave the way for innovative therapeutic solutions and technologies.

Synonyms
BRN 2917038
23189-43-7
2-(3-(N-Ethylacetamido)-2,4,6-triiodophenoxy)-2-(p-tolyl)acetic acid
Acido (4-metilfenil)(3-N-etilacetilamino-2,4,6-triiodofenossi)acetico [Italian]
Benzeneacetic acid, alpha-(3-(acetylethylamino)-2,4,6-triiodophenoxy)-4-methyl-
ACETIC ACID, 2-(3-(N-ETHYLACETAMIDO)-2,4,6-TRIIODOPHENOXY)-2-(p-TOLYL)-
Acido (4-metilfenil)(3-N-etilacetilamino-2,4,6-triiodofenossi)acetico
RefChem:316439
Benzeneacetic acid, alpha-(3-(acetylethylamino)-2,4,6-triiodophenoxy)-4-methyl-(9CI)
DTXSID20945863
{3-[acetyl(ethyl)amino]-2,4,6-triiodophenoxy}(4-methylphenyl)acetic acid