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Ioxaglic acid

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Identification
Molecular formula
C14H16I3NO4
CAS number
59017-51-3
IUPAC name
2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]acetic acid
State
State

At room temperature, Ioxaglic acid is commonly found as a solid. It is often processed into a solution form for medical applications.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
231.50
Boiling point (Kelvin)
504.65
General information
Molecular weight
821.94g/mol
Molar mass
821.9410g/mol
Density
3.3100g/cm3
Appearence

Ioxaglic acid is typically found as a white crystalline powder. It is often used in solutions where it can be clear and colorless.

Comment on solubility

Solubility of 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]acetic acid

The solubility of the compound 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]acetic acid, with the chemical formula C14H16I3NO4, presents interesting characteristics due to its complex structure. Its solubility can be influenced by several factors:

  • Polarity: The presence of multiple iodine atoms in the structure suggests a significant degree of non-polar character, which may lower its solubility in polar solvents like water.
  • Functional Groups: The acetyl and amino groups contribute to the potential for hydrogen bonding, which can enhance solubility in organic solvents.
  • pH Sensitivity: As an acid, the solubility may also vary depending on the pH of the solution, potentially increasing in more alkaline environments.

When assessing solubility, one might consider the following:

  1. Solvent Compatibility: This compound may dissolve better in organic solvents such as ethanol or dimethyl sulfoxide (DMSO).
  2. Temperature Effects: Higher temperatures often increase solubility; thus, examining solubility at various temperatures could yield insightful information.
  3. Concentration: It is essential to consider that saturation levels will impact observable solubility.

In conclusion, while the precise solubility of 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]acetic acid is influenced by multiple layers of molecular interactions, it is likely to exhibit higher solubility in organic solvents compared to aqueous environments due to its unique structure and the presence of hydrophobic iodine atoms. Understanding these nuances is crucial for practical applications and further research.

Interesting facts

Interesting Facts about 2-[3-[Acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]acetic Acid

2-[3-[Acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]acetic acid is a compound that reflects the fascinating interplay of medicinal chemistry and organoiodine chemistry. Here are some notable points:

  • Pharmacological Significance: This compound is of interest in pharmaceutical research, particularly for its potential use in treating various medical conditions due to its iodine content. Iodine is known for its role in thyroid hormone production and thus may influence metabolic processes.
  • Iodine Chemistry: The presence of multiple iodine atoms (triiodo) makes this compound particularly intriguing. Iodine is not only a halogen but also plays significant roles in radiology and imaging studies, enhancing the visualization of biological tissues.
  • Ethylamine Derivative: The acetyl(ethyl)amino group adds an amino functionality to the structure, which can enhance its interaction with biological targets. Amino acids and their derivatives are essential in many biological processes.
  • Synthesis Challenges: The synthesis of compounds like this often involves intricate multi-step processes. Understanding synthetic routes can provide valuable insights into organic synthesis strategies used in the development of complex molecules.
  • Potential for Research: This compound could serve as a framework for further modifications leading to the development of new pharmaceutical agents. The study of structure-activity relationships (SAR) could unveil novel therapeutic avenues.

In summary, 2-[3-[Acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]acetic acid exemplifies the richness of organic chemistry and the versatility of iodine-containing compounds. As researchers continue to explore compounds with unique chemical characteristics, this compound stands out as a potential candidate for exciting discoveries in medicinal and synthetic chemistry.

Synonyms
13080-22-3
2-[3-[acetyl(ethyl)amino]-2,4,6-triiodophenoxy]acetic acid
ACETIC ACID, (3-(N-ETHYLACETAMIDO)-2,4,6-TRIIODOPHENOXY)-
[3-(N-Ethylacetylamino)-2,4,6-triiodophenoxy]acetic acid
BRN 2167433
(3-(N-Ethylacetamido)-2,4,6-triiodophenoxy)acetic acid
DTXSID90156747