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Iothalamic acid

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Identification
Molecular formula
C11H9I3N2O4
CAS number
2276-90-6
IUPAC name
2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]butanoic acid
State
State

At room temperature, Iothalamic acid is in solid form. It is a crystalline powder which is highly stable and is often processed into an aqueous solution for use in medical diagnostics.

Melting point (Celsius)
252.00
Melting point (Kelvin)
525.15
Boiling point (Celsius)
210.00
Boiling point (Kelvin)
483.15
General information
Molecular weight
613.93g/mol
Molar mass
613.9340g/mol
Density
3.2300g/cm3
Appearence

Iothalamic acid appears as a white or almost white crystalline powder. It is odorless and is hygroscopic, meaning it can absorb moisture from the air. In medical applications, it is often encountered in solution form, where it is used as a contrast agent for imaging.

Comment on solubility

Solubility of 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]butanoic acid

The solubility of 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]butanoic acid is influenced by its unique chemical structure, which incorporates various functional groups. Understanding the solubility of this compound is key to its application and utility in various chemical processes. Here are some important considerations:

  • Polarity: The molecule features polar functional groups such as the carboxylic acid and amine moieties, which generally enhance solubility in polar solvents like water.
  • Hydrogen Bonding: The presence of the carboxylic acid allows for hydrogen bonding with water molecules, facilitating its solubility.
  • Iodine Atoms: The triiodo-substitution provides significant molecular weight, which can impact solubility due to increased hydrophobic properties.
  • Solvent Choices: It is likely to be more soluble in organic solvents (e.g., ethanol, methanol) compared to non-polar solvents due to the presence of polar bonds.

Despite these factors, solubility can vary significantly with changes in pH and temperature. Therefore, it is crucial to conduct solubility tests under different conditions to determine its practical applications in chemical formulations.

Interesting facts

Interesting Facts about 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]butanoic acid

This unique compound captures the interest of scientists due to its intricate structure and potential applications. Here are some fascinating aspects of 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]butanoic acid:

  • Complexity in Structure: The presence of multiple functional groups, including an acetyl group, an ethyl amino group, and a triiodo-phenoxy moiety, showcases a remarkable level of complexity that influences its chemical behavior and reactivity.
  • Potential for Drug Development: Compounds with iodine substitution often exhibit biological activities. There is ongoing research into iodine-containing compounds for their use in pharmaceutical applications, particularly in oncology.
  • Applications in Imaging: The triiodo group is known for its use in imaging techniques, such as X-ray contrast agents. This feature could pave the way for this compound's application in medical diagnostics.
  • Synthesis Challenges: The synthesis of this compound may present challenges due to the need for precise control during the addition of iodine and amidation processes, showcasing the art involved in organic chemistry.
  • Environmental Considerations: The incorporation of iodine into organic structures is subject to environmental scrutiny. Researchers are focused on understanding how such compounds interact with biological systems and their environmental impact.

In summary, 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenoxy]butanoic acid is a captivating compound that holds potential for innovative applications in medicine and research. Its unique properties and complex structure continue to inspire chemists to delve deeper into its possibilities.

Synonyms
24340-16-7
2-(3-(N-Ethylacetamido)-2,4,6-triiodophenoxy)butyric acid
BUTYRIC ACID, 2-(3-(N-ETHYLACETAMIDO)-2,4,6-TRIIODOPHENOXY)-
RefChem:331238
2-[3-[acetyl(ethyl)amino]-2,4,6-triiodophenoxy]butanoic acid
2-{3-[Acetyl(ethyl)amino]-2,4,6-triiodophenoxy}butanoic acid
DTXSID10947174