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Iohexol

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Identification
Molecular formula
C19H26I3N3O9
CAS number
66108-95-0
IUPAC name
2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenyl]acetic acid
State
State

Iohexol is a solid at room temperature, typically found in powdered form but is used in solution form for medical applications such as contrast media.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
338.30
Boiling point (Kelvin)
611.45
General information
Molecular weight
821.14g/mol
Molar mass
821.1430g/mol
Density
1.4005g/cm3
Appearence

Iohexol is a white, crystalline powder that is practically odorless. It is soluble in water, providing a clear solution.

Comment on solubility

Solubility of 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenyl]acetic acid

The solubility of 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenyl]acetic acid can be influenced by several factors, including its molecular structure and the presence of iodine substituents. This compound contains a functional group with an acidic nature, which generally contributes to its solubility properties.

Here are some key points regarding its solubility:

  • Polarity: The presence of the acetyl(ethyl)amino group can increase the overall polarity of the molecule, enhancing its interactions with polar solvents such as water.
  • Iodine Substitution: The three iodine atoms contribute to hydrophobic characteristics, which may limit solubility in polar solvents, while possibly increasing solubility in organic solvents.
  • Acidic Nature: As an acid, this compound may exhibit better solubility in alkaline solutions, where it can ionize and form soluble ions.
  • Temperature Dependency: Solubility may also vary with temperature, often increasing in organic solvents at elevated temperatures.

In summary, while this compound may exhibit some solubility in polar solvents, factors such as the hydrophobic nature imparted by iodine and the acidic moiety will play crucial roles in its overall solubility behavior. Studying its solubility in various solvent systems can unveil valuable information about its utility in chemical applications.

Interesting facts

Interesting Facts about 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenyl]acetic acid

This compound is a fascinating member of the family of organic compounds, particularly known for its medicinal applications. Here are some intriguing aspects of this chemical:

  • Designation as a Drug: 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenyl]acetic acid is often categorized under pharmaceutical compounds and has garnered attention for its potential therapeutic uses.
  • Structural Complexity: The structure of this compound is notably complex, featuring a tri-iodinated phenyl group coupled with an acetic acid functionality. This complexity can influence its chemical behavior and interactions within biological systems.
  • Role in Imaging: Compounds that contain iodine, like this one, are often utilized in medical imaging. The iodine atoms can provide significant contrast in imaging techniques such as X-rays or CT scans.
  • Potential as a Diagnostic Tool: Due to its iodine content, this compound may play a role in diagnostics, particularly in visualizing certain conditions within the body, reflecting how chemistry intersects with healthcare.
  • Historical Context: The synthesis and exploration of organoiodine compounds date back to the early 20th century, underscoring a rich history of chemical investigation that has informed modern medicinal chemistry.

As a chemistry student or professional, one can appreciate how the intricate balance of molecular design can lead to significant advancements in medical diagnostics and treatment options. The ongoing research into compounds like 2-[3-[acetyl(ethyl)amino]-2,4,6-triiodo-phenyl]acetic acid not only broadens our understanding of organic chemistry but also highlights its impactful applications in enhancing human health.

Synonyms
BRN 2999827
29193-33-7
ACETIC ACID, (3-(N-ETHYLACETAMIDO)-2,4,6-TRIIODOPHENYL)-
(3-(N-Ethylacetamido)-2,4,6-triiodophenyl)acetic acid
DTXSID40183447
RefChem:316186
DTXCID50105938