Skip to main content

Iopamidol

ADVERTISEMENT
Identification
Molecular formula
C17H22I3N3O8
CAS number
60166-93-0
IUPAC name
2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenoxy]-2-(m-tolyl)acetic acid
State
State

At room temperature, iopamidol is in a solid state, commonly delivered as a powder. It is used in solution form when applied in medical imaging procedures.

Melting point (Celsius)
258.00
Melting point (Kelvin)
531.20
Boiling point (Celsius)
588.80
Boiling point (Kelvin)
862.00
General information
Molecular weight
777.09g/mol
Molar mass
777.0880g/mol
Density
1.6650g/cm3
Appearence

Iopamidol appears as a white to off-white crystalline powder. It is primarily used in medical settings, particularly in diagnostic imaging.

Comment on solubility

Solubility of 2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenoxy]-2-(m-tolyl)acetic acid

The solubility of 2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenoxy]-2-(m-tolyl)acetic acid can be described as follows:

  • General Solubility: This compound is expected to have limited solubility in water due to its complex molecular structure and the presence of multiple aromatic rings.
  • Aromatic Nature: The presence of iodine atoms and aromatic groups often contributes to significant hydrophobic interactions, thus reducing water solubility.
  • Solvents: It may show enhanced solubility in organic solvents such as ethanol, dimethyl sulfoxide (DMSO), or acetone, where nonpolar characteristics facilitate dissolution.
  • Temperature Dependence: Like many compounds, solubility could increase with rising temperatures, suggesting a temperature-dependent solubility profile.
  • pH Influence: The solubility may also be affected by pH levels, particularly if the compound can ionize, highlighting the importance of environmental conditions.

In conclusion, while definitive solubility data may require experimental verification, understanding the underlying factors like solvent polarity, molecular structure, and environmental conditions can provide valuable insights into the solubility characteristics of this compound.

Interesting facts

Interesting Facts About 2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenoxy]-2-(m-tolyl)acetic acid

This compound, with its complex structure, is a fascinating example of the interplay between organic chemistry and medicinal applications. Here are some key points that highlight its significance:

  • Pharmacological Potential: The presence of the acetyl and amine functional groups suggests potential pharmacological activity, which can be explored in drug development.
  • Halogenated Compounds: With three iodine atoms in its structure, this compound falls under the category of halogenated compounds. Halogenation often enhances the lipophilicity, impacting the bioavailability of drugs.
  • Environmental Considerations: Compounds with multiple halogens can pose environmental challenges. Understanding their degradation pathways is crucial for assessing their long-term impact.
  • Structure-Activity Relationship (SAR): This compound serves as an excellent model for studying SAR, aiding chemists in predicting how modifications to its structure could influence biological activity.
  • Intermolecular Interactions: The molecular interactions of this compound can be intricate due to its multiple functional groups, making it an interesting subject for studies related to drug binding and receptor interactions.

As a scientist or chemistry student, exploring 2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenoxy]-2-(m-tolyl)acetic acid not only hones your understanding of organic synthesis and functional group chemistry but also opens avenues to potentially groundbreaking research in pharmacology. The complexity of its structure embodies the challenge and excitement of modern chemical research.

Synonyms
BRN 2914368
23189-47-1
2-(3-(N-Methylacetamido)-2,4,6-triiodophenoxy)-2-(m-tolyl)acetic acid
Acido (3-metilfenil)(3-N-metilacetilamino-2,4,6-triiodofenossi)acetico [Italian]
Benzeneacetic acid, alpha-(3-(acetylmethylamino)-2,4,6-triiodophenoxy)-3-methyl-
ACETIC ACID, 2-(3-(N-METHYLACETAMIDO)-2,4,6-TRIIODOPHENOXY)-2-(m-TOLYL)-
Acido (3-metilfenil)(3-N-metilacetilamino-2,4,6-triiodofenossi)acetico
RefChem:316442
Benzeneacetic acid, alpha-(3-(acetylmethylamino)-2,4,6-triiodophenoxy)-3-methyl-(9CI)
DTXSID60945867
{3-[acetyl(methyl)amino]-2,4,6-triiodophenoxy}(3-methylphenyl)acetic acid