Skip to main content

Iohexol

ADVERTISEMENT
Identification
Molecular formula
C19H26I3N3O9
CAS number
66108-95-0
IUPAC name
2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenoxy]-2-(o-tolyl)acetic acid
State
State

At room temperature, Iohexol is a solid. It is often used as a solution for medical imaging due to its excellent solubility in water, providing contrast in X-ray procedures.

Melting point (Celsius)
43.00
Melting point (Kelvin)
316.15
Boiling point (Celsius)
258.00
Boiling point (Kelvin)
531.15
General information
Molecular weight
821.14g/mol
Molar mass
821.1400g/mol
Density
1.4000g/cm3
Appearence

Iohexol is a white to off-white crystalline powder. It is typically odorless and is hygroscopic, meaning it can absorb moisture from the air. This compound is often used in a dissolved form.

Comment on solubility

Solubility of 2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenoxy]-2-(o-tolyl)acetic acid

2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenoxy]-2-(o-tolyl)acetic acid is a complex chemical compound whose solubility can be influenced by various factors. Its intricate molecular structure, featuring both hydrophobic and hydrophilic components, suggests a nuanced solubility profile.

Factors Affecting Solubility

  • Polarity: The presence of the carboxylic acid group contributes to polar characteristics, potentially enhancing solubility in polar solvents like water.
  • Iodine Substituents: The tri-iodo substitution introduces significant non-polar attributes, which may limit solubility in aqueous mediums.
  • Temperature: As with many organic compounds, increased temperature can enhance solubility, making the compound more readily dissolvable in appropriate solvents.
  • pH Levels: The ionization state of the carboxylic acid can affect solubility, with lower pH favoring its protonated, less soluble form.

In summary, this compound may exhibit:

  • Moderate solubility in organic solvents, due to the hydrophobic character influenced by iodine and aromatic rings.
  • Variable solubility in water, which can be affected by pH adjustments and temperature modifications.

Overall, understanding the solubility dynamics of this compound requires consideration of both its molecular structure and external conditions. As a general observation, it is important to perform empirical testing to establish precise solubility characteristics in specific environments.

Interesting facts

Interesting Facts about 2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenoxy]-2-(o-tolyl)acetic acid

This intriguing compound is notable for its complex structure and unique applications. Here are some fascinating insights that make it stand out:

  • Diverse Utility: This compound is often examined for its roles in pharmaceuticals and biochemistry, showcasing the blend of organic chemistry and medicinal uses.
  • Iodine Atoms: The presence of three iodine atoms in its structure contributes unique properties, especially in imaging techniques such as PET scans, enhancing contrast and resolution.
  • Acetyl Group: The acetyl(methyl)amino functional group allows for intriguing interactions with biological systems, which can lead to innovative therapeutic approaches.
  • Phenoxy and Tolyl moieties: These aromatic components provide stability and influence the compound's interactions, making it a subject of study in both chemical and biological contexts.
  • Research Potential: As scientists explore its potential applications, there is a growing interest in this compound for developing new drugs and treatment methodologies, reflecting its versatility.

In summary, 2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenoxy]-2-(o-tolyl)acetic acid is not just a compound with an interesting chemical structure; it represents a bridge between chemistry and practical applications in medicine, offering a window into the possibilities of therapeutic development.

Synonyms
BRN 2915809
23197-57-1
2-(3-(N-Methylacetamido)-2,4,6-triiodophenoxy)-2-(o-tolyl)acetic acid
Acido (2-metilfenil)(3-N-metilacetilamino-2,4,6-triiodofenossi)acetico [Italian]
Benzeneacetic acid, alpha-(3-(acetylmethylamino)-2,4,6-triiodophenoxy)-2-methyl-
ACETIC ACID, 2-(3-(N-METHYLACETAMIDO)-2,4,6-TRIIODOPHENOXY)-2-(o-TOLYL)-
Acido (2-metilfenil)(3-N-metilacetilamino-2,4,6-triiodofenossi)acetico
RefChem:316443
Benzeneacetic acid, alpha-(3-(acetylmethylamino)-2,4,6-triiodophenoxy)-2-methyl-(9CI)
DTXSID90945875
{3-[acetyl(methyl)amino]-2,4,6-triiodophenoxy}(2-methylphenyl)acetic acid