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Iopamidol

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Identification
Molecular formula
C17H22I3N3O8
CAS number
60166-93-0
IUPAC name
2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenyl]acetic acid
State
State

Iopamidol is typically found in a solid state at room temperature. It is often used in a medical setting as a sterile aqueous solution for injection.

Melting point (Celsius)
290.00
Melting point (Kelvin)
563.15
Boiling point (Celsius)
687.00
Boiling point (Kelvin)
960.15
General information
Molecular weight
777.09g/mol
Molar mass
777.0880g/mol
Density
2.2260g/cm3
Appearence

Iopamidol is a white to off-white crystalline powder. It is typically odorless and has a bitter taste. This compound is often used in a medical setting, where it is dissolved in solutions for administration as a contrast agent.

Comment on solubility

Solubility of 2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenyl]acetic acid

The solubility of 2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenyl]acetic acid is an intriguing aspect to consider due to its unique structure and functional groups.

Key points regarding its solubility include:

  • Polarity: The presence of polar functional groups, such as the acetyl and amino components, may enhance solubility in polar solvents like water.
  • Halogen Influence: The three iodine atoms in the molecule introduce a significant degree of non-polar character, which could lead to reduced solubility in aqueous environments.
  • Acidic Nature: As a carboxylic acid, this compound can ionize in solution, potentially increasing its solubility in water, especially at elevated pH levels where the carboxyl group is deprotonated.
  • Drug Solubility: Given its complex structure, solubility can be influenced by interactions with biological membranes, affecting its absorption in pharmaceutical applications.

In summary, while the hydrophilic aspects of the molecule promote solubility in water, the contradictory effects of the triiodinated structure may hinder it. Ultimately, the solubility profile of this compound will depend on various factors, including concentration, temperature, and the presence of co-solvents or surfactants.

Interesting facts

Interesting Facts about 2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenyl]acetic acid

This compound, known for its unique structure and impressive properties, is part of a family of compounds that possess potent biological activities. Here are some engaging highlights:

  • Versatile Applications: This compound is frequently utilized in pharmacology and medicinal chemistry, particularly in the development of pharmaceuticals that regulate various physiological processes.
  • Structural Complexity: The presence of multiple iodine atoms significantly influences the compound's reactivity and biological interactions, making it a subject of interest in organic synthesis.
  • Potential for Novel Compounds: Chemists explore derivatives of this compound in the quest for new therapies. The acetyl and methyl groups contribute to its varied electrophilic properties, leading to diverse functionalities.

Interesting Quote: "Understanding the subtleties of chemical structure can unlock the doors to innovative treatments and materials." – Anonymous Scientist

The compound's intricate design allows it to interact with specific biological targets, enhancing its importance in research. It serves as a prime example of how chemical modifications can lead to significant improvements in efficacy and selectivity in drug design.

In summary, 2-[3-[acetyl(methyl)amino]-2,4,6-triiodo-phenyl]acetic acid illustrates the beauty of chemistry, where structural variations can lead to vastly different properties and applications!

Synonyms
29193-32-6
BRN 2391514
ACETIC ACID, (3-(N-METHYLACETAMIDO)-2,4,6-TRIIODOPHENYL)-
(3-(N-Methylacetamido)-2,4,6-triiodophenyl)acetic acid
DTXSID80183446
RefChem:316189
DTXCID90105937