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Histidine

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Identification
Molecular formula
C6H9N3O2
CAS number
71-00-1
IUPAC name
2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
State
State

At room temperature, histidine is a solid.

Melting point (Celsius)
277.00
Melting point (Kelvin)
550.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
155.16g/mol
Molar mass
155.1550g/mol
Density
1.4100g/cm3
Appearence

Histidine appears as a white crystalline powder. It is usually odorless and is often provided in its monohydrochloride or monohydrate form for biological and chemical applications.

Comment on solubility

Solubility of 2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid

The solubility of 2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid is a fascinating topic due to its unique structure and functional groups, which influence its behavior in various solvents.

  • Water Solubility: This compound is expected to be highly soluble in water due to the presence of multiple polar amino groups and a carboxylic acid functionality, which can form hydrogen bonds with water molecules.
  • Organic Solvents: While it may have limited solubility in non-polar organic solvents, it can potentially dissolve in polar aprotic solvents, given the right conditions.

Factors that can affect its solubility include:

  1. pH Level: The solubility can vary significantly with changes in pH, particularly because of the acidic functional group.
  2. Temperature: Increasing the temperature generally enhances solubility for most compounds, and this one is no exception.
  3. Concentration: At higher concentrations, precipitation may occur due to saturation limits in the solvent.

In summary, the solubility characteristics of 2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid highlight its potential applications in biochemical contexts, where solubility is essential for interaction with biomolecules. With its polar nature and ability to engage in hydrogen bonding, it stands out as a versatile compound in aqueous solutions.

Interesting facts

Interesting Facts about 2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic Acid

This compound, often referred to in the realm of biochemistry and medicinal chemistry, showcases fascinating properties and potential applications:

  • Amino Acid Derivative: This compound represents a unique class of amino acid derivatives, with a structure that incorporates both an amino group and an imidazole ring, which may influence biological activity.
  • Biological Relevance: Due to its imidazole moiety, the compound could play a role in biological systems, as imidazole is found in histidine, an essential amino acid involved in many enzymatic reactions.
  • Potential Therapeutic Applications: Researchers are exploring compounds similar to this one for potential uses in drug design, particularly in the treatment of diseases where modulation of amino acid metabolism is crucial.
  • Functionality: The dual functional groups (the amino acid side chain and the imidazole) make this compound an interesting candidate for synthesis in the development of peptide-based drugs.
  • Research Interest: Scientists are particularly intrigued by how the presence of the imidazole ring can affect the compound's interaction with biological receptors and enzymes, making it a topic of ongoing research.

In conclusion, the study of 2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid is a remarkable representation of the intersection of synthetic chemistry and biochemistry, highlighting the intricate relationship between chemical structure and biological function.

Synonyms
9001-99-4
9001-73-4
Nuclease, ribo-
Ribonuclease A
L-HISTIDINE, N-beta-ALANYL-
2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanoic acid
DL-(3-aminopropanoyl)histidine
108333-82-0
2-(3-aminopropanamido)-3-(1H-imidazol-5-yl)propanoic acid
B-Ala-his-oh
L-Histidine, .beta.-alanyl-
L-Histidine, N-.beta.-alanyl-
DTXSID50861860
Velardon;Vermizym
SCHEMBL33768
Carnosine; Karnozin; Karnozzn
CHEMBL18545
CQOVPNPJLQNMDC-UHFFFAOYSA-N
ss-Alanyl-L-Histidine [Carnosine]
BCP13131
OAH-3085
NSC524045
AKOS015905612
AKOS030238597
FP72023
DA-56585
DA-57439
NCI60_004277
SY040645
NS00014799
EN300-717716
BRD-A96051074-001-02-2
2-(3-amino-propanoylamino)-3-(1H-imidazol-4-yl)-propionic acid
L-Carnosin, L-Carnosine, Beta-Alanyl-L-histidine, Beta-Ala-His-OH