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Histidine

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Identification
Molecular formula
C6H9N3O2
CAS number
71-00-1
IUPAC name
2-(3-aminopropanoylamino)-3-(3-methylimidazol-4-yl)propanoic acid
State
State

Histidine is typically found as a solid at room temperature. It is stable under normal conditions, but can be hygroscopic, which means it may absorb moisture from the air and become slightly sticky if exposed to high humidity.

Melting point (Celsius)
282.00
Melting point (Kelvin)
555.00
Boiling point (Celsius)
273.00
Boiling point (Kelvin)
546.00
General information
Molecular weight
155.16g/mol
Molar mass
155.1550g/mol
Density
1.4470g/cm3
Appearence

Histidine is a white crystalline solid that is odorless. It generally appears as either a fine powder or as small granules. Its crystalline structure gives it a shiny or reflective appearance under light.

Comment on solubility

Solubility of 2-(3-aminopropanoylamino)-3-(3-methylimidazol-4-yl)propanoic acid

The solubility of 2-(3-aminopropanoylamino)-3-(3-methylimidazol-4-yl)propanoic acid, a complex amino acid derivative, is influenced by various factors related to its structure and functional groups. This compound contains both hydrophilic and hydrophobic portions, which significantly affect its solubility in different solvents.

  • Hydrophilicity: The presence of amino groups in the molecular structure enhances solubility in polar solvents, particularly water. This occurs due to the capacity of the amino groups to form hydrogen bonds with water molecules.
  • Hydrophobic Interactions: The 3-methylimidazol-4-yl group introduces a certain degree of hydrophobic character, which can limit solubility in highly polar solvents.
  • pH Considerations: The solubility may also vary with pH. At different pH levels, the ionization of the carboxylic acid group can either increase or decrease solubility, indicating that adjusting pH may lead to enhanced dissolution.

In summary, the solubility of 2-(3-aminopropanoylamino)-3-(3-methylimidazol-4-yl)propanoic acid is a delicate balance between its hydrophilic and hydrophobic characteristics. As noted, understanding the environmental factors such as solvent type and pH can provide valuable insights into its solubility behavior:

  1. Water solubility: Generally favorable due to polar functional groups.
  2. Organic solvent solubility: Potentially limited, depending on solvent polarity.

Ultimately, the solubility profile of this compound reflects its complex chemical nature, making it an intriguing subject for further study in both biochemical applications and pharmaceutical formulations.

Interesting facts

Interesting Facts about 2-(3-Aminopropanoylamino)-3-(3-methylimidazol-4-yl)propanoic Acid

This intriguing compound serves a crucial role in the realm of biochemistry, particularly in the study of amino acids and their derivatives. Understanding its structure and function can reveal much about biological processes.

Biological Significance

2-(3-Aminopropanoylamino)-3-(3-methylimidazol-4-yl)propanoic acid has several noteworthy applications:

  • Amino Acid Derivative: This compound can be viewed as a modified amino acid, which may impact protein synthesis and enzyme function.
  • Potential Role in Metabolism: It is vital to investigate how its unique side chains contribute to metabolic pathways.
  • Pharmaceutical Applications: Given its structure, this compound could lead to the development of new medications targeting various biological functions.

Structural Insights

The compound is characterized by the presence of a 3-methylimidazol-4-yl group. This imidazole ring is noteworthy for several reasons:

  • Stability: The imidazole ring can contribute to the stability and reactivity of the molecule.
  • Biodiversity: The incorporation of non-standard amino acid elements enhances the diversity of proteins that can form.
  • Interactions: The unique structure may allow for specific interactions with biological receptors, influencing signal transduction.

Future Research Directions

Investigating compounds like 2-(3-aminopropanoylamino)-3-(3-methylimidazol-4-yl)propanoic acid opens doors to numerous research questions:

  • Mechanistic Studies: Understanding its action mechanism could provide insights into therapeutic strategies.
  • Analytical Chemistry: Developing methods to quantify this compound in biological samples is essential for its study.
  • Chemical Modifications: Exploring how altering functional groups affects its properties and functions might yield valuable information.

In summary, the exploration of 2-(3-aminopropanoylamino)-3-(3-methylimidazol-4-yl)propanoic acid not only enriches our understanding of amino acid chemistry but also has far-reaching implications in pharmacology and biochemical research. As we dive deeper into this compound, we continue to uncover its potential and expand its applications in the scientific community.

Synonyms
beta-alanyl-3-methyl-L-histidine
beta-Ala-3-methyl-His
MFCD11040910
L-Histidine, N-beta-alanyl-3-methyl-
bmse000776
bmse001004
SCHEMBL2771107
SMP1_000024
SY105498