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Varenicline

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Identification
Molecular formula
C13H17N3
CAS number
249296-44-4
IUPAC name
2-(3-azabicyclo[3.2.2]nonan-3-yl)acetonitrile
State
State

At room temperature, Varenicline is typically found in a solid state, specifically as a crystalline powder. It is stable under standard conditions and is usually supplied in its tartrate form for better solubility and stability.

Melting point (Celsius)
226.00
Melting point (Kelvin)
499.15
Boiling point (Celsius)
287.48
Boiling point (Kelvin)
560.63
General information
Molecular weight
211.29g/mol
Molar mass
211.2920g/mol
Density
1.3370g/cm3
Appearence

Varenicline typically appears as a white to off-white crystalline powder. It is odorless and is generally provided in its tartrate salt form for pharmaceutical applications.

Comment on solubility

Solubility of 2-(3-azabicyclo[3.2.2]nonan-3-yl)acetonitrile

The solubility of 2-(3-azabicyclo[3.2.2]nonan-3-yl)acetonitrile is an intriguing topic due to its unique structural features. Understanding the factors affecting its solubility can provide insight into its behavior in various environments.

Key Factors Influencing Solubility:

  • Polarity: The compound contains functional groups such as acetonitrile, which is polar, potentially enhancing its solubility in polar solvents.
  • Hydrogen Bonding: The presence of nitrogen in the bicyclic structure hints at possible hydrogen bonding, which may affect solubility.
  • Size and Shape: The bicyclo structure may contribute to steric hindrance, which can hinder solubility in certain solvents.

In general, it can be assumed that 2-(3-azabicyclo[3.2.2]nonan-3-yl)acetonitrile may display variable solubility depending on the solvent used. For example:

  1. In polar solvents: It is likely to have a higher solubility due to favorable interactions.
  2. In non-polar solvents: The solubility may be significantly reduced due to incompatibility with non-polar environments.

Ultimately, while we acknowledge that general trends can be predicted, the precise solubility of this compound would require empirical testing to fully elucidate its behavior in different chemical settings.

Interesting facts

Interesting Facts about 2-(3-azabicyclo[3.2.2]nonan-3-yl)acetonitrile

2-(3-azabicyclo[3.2.2]nonan-3-yl)acetonitrile is an intriguing compound with several noteworthy characteristics that make it a point of interest in the field of chemistry:

  • Structure and Framework: The compound features a unique bicyclic structure that contributes to its stability and reactivity. Its azabicyclic nature, referring to the incorporation of nitrogen into the bicyclic framework, is quite fascinating and can impact its chemical behavior significantly.
  • Potential Applications: Due to its structure, this compound holds potential for applications in medicinal chemistry. Compounds with similar structural features often exhibit interesting biological activities, which can lead to the development of new pharmaceutical agents.
  • Synthesis Insights: The synthesis of such bicyclic compounds often involves complex reaction pathways. Understanding these reactions can provide vital insights into synthetic organic chemistry and help chemists develop new methodologies for constructing intricate molecular architectures.
  • Reactivity: The presence of both a bicyclic moiety and an acetonitrile functional group suggests that 2-(3-azabicyclo[3.2.2]nonan-3-yl)acetonitrile might engage in diverse reactions. For example, nucleophilic substitutions or potential rearrangements could be explored, opening pathways for further research.
  • Research Significance: This type of compound is often studied not just for its own properties but also for what it can teach us about larger classes of compounds. The behaviors of 2-(3-azabicyclo[3.2.2]nonan-3-yl)acetonitrile may have implications for understanding reaction mechanisms and molecular interactions.

In summary, 2-(3-azabicyclo[3.2.2]nonan-3-yl)acetonitrile serves as a testament to the complex nature of organic compounds. The study of this compound not only enhances our grasp of its unique characteristics but can lead to broader insights into organic synthesis and biological activity.

Synonyms
1199-73-1
BRN 1423774
3-AZABICYCLO(3.2.2)NONANE-3-ACETONITRILE
3-Cyanomethyl-3-azabicyclo(3.2.2)noname
3-Azabicyclo(3.2.2)nonane, 3-cyanomethyl-
Acetonitrile, (3-azabicyclo(3.2.2)nonanyl)-
DTXSID00152619
5-20-04-00383 (Beilstein Handbook Reference)
DTXCID4075110