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Thiotepa

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Identification
Molecular formula
C9H14N2O4
CAS number
52-24-4
IUPAC name
2-[3-(aziridin-1-yl)propanoyloxy]ethyl 3-(aziridin-1-yl)propanoate
State
State

Thiotepa is typically in a solid state at room temperature.

Melting point (Celsius)
52.00
Melting point (Kelvin)
325.15
Boiling point (Celsius)
262.00
Boiling point (Kelvin)
535.15
General information
Molecular weight
189.24g/mol
Molar mass
189.2370g/mol
Density
1.2100g/cm3
Appearence

Thiotepa is a colorless crystalline solid. It is typically found in a powdered form for medicinal applications.

Comment on solubility

Solubility of 2-[3-(aziridin-1-yl)propanoyloxy]ethyl 3-(aziridin-1-yl)propanoate

The solubility of 2-[3-(aziridin-1-yl)propanoyloxy]ethyl 3-(aziridin-1-yl)propanoate exhibits unique characteristics that are influenced by its molecular structure. Understanding its solubility can be crucial for various applications in chemical synthesis and biochemistry. Here are some key points regarding its solubility:

  • Polar and Nonpolar Interactions: This compound has functional groups that can engage in hydrogen bonding, which may increase its solubility in polar solvents like water.
  • Organic Solvents: It is likely to be more soluble in organic solvents such as ethanol or acetone, due to the hydrophobic regions in its molecular structure.
  • Temperature Dependence: Like many compounds, its solubility may vary with temperature; generally, higher temperatures tend to increase solubility in most solvents.
  • pH Influence: Changes in pH can also affect its solubility, especially if acidic or basic conditions are applied which could protonate or deprotonate functional groups.

In summary, understanding the solubility of 2-[3-(aziridin-1-yl)propanoyloxy]ethyl 3-(aziridin-1-yl)propanoate is essential, as it not only influences its behavior in chemical reactions but also its potential use in pharmaceutical applications. As with many aziridine derivatives, the presence of the aziridinyl groups may introduce unique solubility properties that warrant further investigation.

Interesting facts

Interesting Facts about 2-[3-(aziridin-1-yl)propanoyloxy]ethyl 3-(aziridin-1-yl)propanoate

This intriguing compound belongs to a class of molecules known for their role in various biological processes. Here are some fascinating aspects of 2-[3-(aziridin-1-yl)propanoyloxy]ethyl 3-(aziridin-1-yl)propanoate:

  • Unique Structure: The presence of aziridine, a three-membered nitrogen-containing heterocycle, provides unique reactivity and properties. This configuration is often associated with interesting chemical behaviors that make it a valuable building block in organic synthesis.
  • Biological Activity: Compounds with aziridine motifs have been investigated for their potential in medicinal chemistry, particularly as anticancer agents. Their ability to interact with biological macromolecules puts them at the forefront of research into new therapeutic options.
  • Modular Design: The compound is designed in a way that allows for easy modification. Scientists can alter various portions of the molecule to explore its effects further, making it a versatile candidate for drug development.
  • Research Potential: Ongoing research into aziridine-containing compounds is uncovering new therapeutic pathways. This compound may serve as a starting point for generating libraries of similar molecules that could enhance drug discovery initiatives.
  • Synthetic Applications: Due to the aziridine ring's strain, this compound is an excellent precursor for creating more complex molecules. Its reactivity can be harnessed in various synthetic pathways to develop innovative compounds.

In summary, 2-[3-(aziridin-1-yl)propanoyloxy]ethyl 3-(aziridin-1-yl)propanoate is more than just a name; it’s a gateway into the realm of potential therapeutic agents, showcasing the fascinating interplay between structure and function in the world of chemistry.

Synonyms
1-AZIRIDINEPROPIONIC ACID, ETHYLENE ESTER
Ethylene 1-aziridinepropionate
4128-83-0
V5SH1NC5YC
MLS002608401
NSC-42399
NSC 42399
Ethanediol, bis(1-aziridinepropionate)
BRN 1584692
1-Aziridinepropanoic acid, ethylene ester
UNII-V5SH1NC5YC
SCHEMBL673537
CHEMBL1899531
DTXSID30194188
HMS3092F05
NSC42399
SMR001527150
ETHYLENE BIS(.BETA.-ETHYLENIMINO)PROPIONATE
ETHYLENE GLYCOL, BIS(1-AZIRIDINEPROPIONATE)
ETHYLENEBIS(.BETA.-N-ETHYLENEIMINO)PROPIONATE
1-AZIRIDINEPROPANOIC ACID, 1,2-ETHANEDIYL ESTER
BIS-.BETA.-ETHYLENE IMINOPROPIONIC ACID, ETHYLENE ESTER