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Buclizine

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Identification
Molecular formula
C18H22N4
CAS number
129-74-8
IUPAC name
2-[3-(benzylamino)propyl]guanidine
State
State

Buclizine is typically in a solid state at room temperature. It appears as a crystalline powder and is commonly used in pharmaceutical formulations.

Melting point (Celsius)
151.00
Melting point (Kelvin)
424.00
Boiling point (Celsius)
277.00
Boiling point (Kelvin)
550.00
General information
Molecular weight
282.39g/mol
Molar mass
282.3940g/mol
Density
1.1174g/cm3
Appearence

Buclizine is typically found as a white or off-white, crystalline powder. It may appear slightly yellowish in certain formulations. The powder may also have a characteristic odor.

Comment on solubility

Solubility of 2-[3-(benzylamino)propyl]guanidine

2-[3-(benzylamino)propyl]guanidine is a specialized compound with unique solubility characteristics. When assessing its solubility, it is important to consider the following factors:

  • Solvent Interaction: This compound is likely to show varying solubility in different solvents. Polar solvents, such as water and alcohols, may enhance its solubility due to the presence of the guanidine group, which can engage in hydrogen bonding.
  • Hydrophobic Regions: The benzylamino group introduces a hydrophobic character, which can lead to lower solubility in water. This dual nature means that understanding solvent choices is crucial for achieving optimal solubility.
  • Concentration and Temperature: Like many compounds, its solubility can be influenced by temperature and concentration. As temperatures rise, solubility often increases; hence, experimenting under various thermal conditions may yield better results.

In conclusion, while 2-[3-(benzylamino)propyl]guanidine shows promise for solubility in polar solvents, the complex interplay between its hydrophobic and hydrophilic components necessitates further investigation. Understanding these dynamics is essential for its effective application in various chemical contexts.

Interesting facts

Interesting Facts about 2-[3-(Benzylamino)propyl]guanidine

2-[3-(Benzylamino)propyl]guanidine is a fascinating compound, especially notable for its role in medicinal chemistry. This molecule is a derivative of guanidine, which primarily finds use in the development of therapeutics for various health conditions. Here are some interesting aspects:

  • Pharmacological Applications: The compound has been studied for its potential in treating certain cardiovascular diseases by modulating nitric oxide pathways, thereby impacting vascular function.
  • Structural Importance: The presence of the benzyl group in its structure adds significant potency and selectivity to its biological activity, allowing for enhanced interactions with biological targets.
  • Synergistic Effects: When combined with other pharmacological agents, 2-[3-(Benzylamino)propyl]guanidine can demonstrate synergistic effects, increasing the efficacy of treatments.
  • Research and Development: Ongoing research is focused on its use in understanding the mechanisms of action related to cell signaling and receptor activation, making it a compound of interest in neurobiology.
  • Analog Studies: Scientists are investigating various analogs of this compound to fine-tune its biological activity and minimize potential side effects, a crucial step in drug development.

In summary, 2-[3-(Benzylamino)propyl]guanidine is not just a simple aromatic compound; it highlights the intricate balance between structure and function in pharmacology. As research continues, it may lead to exciting new therapies that could significantly impact patient outcomes.