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Iodixanol

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Identification
Molecular formula
C35H44I6N6O15
CAS number
92339-11-2
IUPAC name
2-[3-[butanoyl(ethyl)amino]-2,4,6-triiodo-phenyl]acetic acid
State
State

At room temperature, Iodixanol is typically encountered as a solid when pure. In medical settings, it is often in aqueous solution form, appearing as a clear, colorless to pale yellow liquid.

Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
200.00
Boiling point (Kelvin)
473.15
General information
Molecular weight
1550.20g/mol
Molar mass
1 550.1980g/mol
Density
2.3700g/cm3
Appearence

Iodixanol is a white to off-white crystalline powder. It is typically used in solution form as a contrast agent in medical imaging.

Comment on solubility

Solubility of 2-[3-[butanoyl(ethyl)amino]-2,4,6-triiodo-phenyl]acetic acid

The solubility of 2-[3-[butanoyl(ethyl)amino]-2,4,6-triiodo-phenyl]acetic acid can be influenced by several factors, given its complex structure. Understanding its solubility properties is essential for applications in pharmaceuticals and other chemical processes.

Key Factors Affecting Solubility

  • Polarity: The presence of polar functional groups such as the carboxylic acid (-COOH) can enhance water solubility.
  • Hydrophobic Interactions: The butanoyl chain and the triiodinated aromatic system may lead to hydrophobic characteristics, affecting solubility in non-polar solvents.
  • Temperature: Solubility can increase with temperature; thus, higher temperatures may facilitate dissolution.
  • pH Level: The solubility of acids is often pH-dependent; the ionization state at varying pH levels will play a role in its solubility in aqueous solutions.

It is often observed that larger, more complex molecules like this one tend to show varying solubilities in different solvents. Generally, compounds with both polar and non-polar regions may try to achieve a balance in specific mediums:

  1. In non-polar solvents, solubility may be low due to hydrophobic character.
  2. In polar solvents like water, solubility may increase significantly when ionization occurs.
  3. Solubility in organic solvents may also vary based on the solvent's polarity.

As a general guideline, “the principle of like dissolves like” often applies, meaning this compound may have better solubility in polar organic solvents. Engineers and scientists must conduct specific empirical tests to quantify its solubility effectively.

Interesting facts

About 2-[3-[butanoyl(ethyl)amino]-2,4,6-triiodo-phenyl]acetic acid

2-[3-[butanoyl(ethyl)amino]-2,4,6-triiodo-phenyl]acetic acid is a fascinating compound that showcases the intricate relationship between structure and function in medicinal chemistry. This compound is a derivative of an amino acid, which means it plays a significant role in biological systems.

Interesting Characteristics:

  • Multiple Functional Groups: The presence of both an amide and a carboxylic acid group in its structure makes it quite versatile for various chemical reactions.
  • Halogenated Phenyl Ring: The triiodinated phenyl aspect not only contributes to its unique chemical properties but also enhances its potential biological activity. Halogens often enhance the binding affinity of compounds to biological targets.
  • Potential Applications: Compounds with structural similarities are frequently explored as pharmaceuticals, especially due to their ability to interact with biochemical pathways.
  • Structure-Activity Relationships (SAR): The modifications in this compound can be pivotal for understanding how changes in molecular structure impact biological actions, providing essential insights for drug development.

As a student of chemistry, exploring compounds like this can lead to exciting discoveries in drug design and development. The *interaction* of the functional groups can provide clues to optimizing potency and selectivity in therapeutic agents. It's a reminder of how impactful the manipulation of molecular architecture can be in the world of chemistry and pharmacology!

Synonyms
BRN 3006972
29193-38-2
ACETIC ACID, (3-(N-ETHYLBUTYRAMIDO)-2,4,6-TRIIODOPHENYL)-
(3-(N-Ethylbutyramido)-2,4,6-triiodophenyl)acetic acid
DTXSID90183452
RefChem:316187
DTXCID00105943