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Iohexol

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Identification
Molecular formula
C19H26I3N3O9
CAS number
66108-95-0
IUPAC name
2-[3-[butanoyl(propyl)amino]-2,4,6-triiodo-phenyl]acetic acid
State
State

Iohexol is typically in a solid state as a powder at room temperature. Due to its high water solubility, it is often used in a dissolved form for various applications.

Melting point (Celsius)
168.00
Melting point (Kelvin)
441.15
Boiling point (Celsius)
315.00
Boiling point (Kelvin)
588.15
General information
Molecular weight
821.14g/mol
Molar mass
821.1440g/mol
Density
3.2706g/cm3
Appearence

Iohexol appears as a white crystalline powder. It is highly soluble in water, which makes it ideal for use in medical imaging.

Comment on solubility

Solubility of 2-[3-[butanoyl(propyl)amino]-2,4,6-triiodo-phenyl]acetic acid

The solubility of 2-[3-[butanoyl(propyl)amino]-2,4,6-triiodo-phenyl]acetic acid can be influenced by several factors due to its complex chemical structure. Generally, the presence of the triiodo substituents can lead to increased hydrophobicity, potentially limiting solubility in water.

  • Polar Functional Groups: The acetic acid moiety introduces a polar character, which can enhance solubility in polar solvents.
  • Hydrophobic Regions: The butanoyl and propyl groups may confer hydrophobic characteristics, which can hinder solubility in aqueous environments.
  • Temperature Effects: As temperature increases, solubility may improve due to the enhancement of molecular movement.

Overall, while one could expect some degree of solubility in organic solvents, solubility in water may be quite limited. As a rule of thumb, compounds that contain a significant number of hydrophobic groups tend to exhibit lower solubility in aqueous solutions. It is important to experimentally determine the solubility of this compound in various solvents to obtain precise data.

Interesting facts

Interesting Facts about 2-[3-[butanoyl(propyl)amino]-2,4,6-triiodo-phenyl]acetic acid

This fascinating compound represents a unique intersection of organic chemistry and medicinal applications. Characterized by its complex structure, 2-[3-[butanoyl(propyl)amino]-2,4,6-triiodo-phenyl]acetic acid showcases the following intriguing aspects:

  • Functional Groups: The presence of both acetic acid and an amine group allows for interesting interactions and potential biological activity. The butanoyl and propyl groups may influence the hydrophobic characteristics and lipophilicity of the molecule, making it attractive for drug design.
  • Triiodo Phenyl Ring: The 2,4,6-triiodo substitution pattern on the phenyl ring introduces significant electron-withdrawing effects. This property often enhances a compound's reactivity, particularly in electrophilic aromatic substitutions.
  • Medical Potential: Compounds with triiodinated structures are of significant interest in the medical field, especially in imaging techniques like X-ray or CT scans. The iodine atoms enhance contrast, making such compounds vital for diagnostic applications.
  • Research Opportunities: With the increasing focus on derivatives of amino-acids and their utilization in therapeutic agents, this compound opens pathways for further research in pharmacology and biochemistry.

One fascinating quote comes to mind for chemists working with complex organic compounds: "The beauty of chemistry lies in the intricate dance of atoms, where each structure tells a unique story." This compound indeed tells a story of innovation, potential, and the ongoing exploration of chemical intricacies.

In conclusion, studying 2-[3-[butanoyl(propyl)amino]-2,4,6-triiodo-phenyl]acetic acid not only deepens our understanding of chemical interactions but also encourages the quest for novel therapeutic agents in modern medicine.

Synonyms
BRN 3007360
29193-39-3
ACETIC ACID, (3-(N-PROPYLBUTYRAMIDO)-2,4,6-TRIIODOPHENYL)-
(3-(N-Propylbutyramido)-2,4,6-triiodophenyl)acetic acid
DTXSID50183453
RefChem:316193
DTXCID60105944