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Fluazinam

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Identification
Molecular formula
C13H9Cl2N3O3
CAS number
79622-59-6
IUPAC name
2-(3-chloro-2-methyl-anilino)pyridine-3-carboxylic acid
State
State
At room temperature, Fluazinam is in a solid state.
Melting point (Celsius)
112.00
Melting point (Kelvin)
385.15
Boiling point (Celsius)
518.00
Boiling point (Kelvin)
791.15
General information
Molecular weight
465.77g/mol
Molar mass
465.7670g/mol
Density
1.5003g/cm3
Appearence
Fluazinam typically appears as an off-white to light brown crystalline solid. Its solid state is often in the form of fine powdery particles.
Comment on solubility

Solubility of 2-(3-chloro-2-methyl-anilino)pyridine-3-carboxylic acid

The solubility of 2-(3-chloro-2-methyl-anilino)pyridine-3-carboxylic acid can be influenced by several factors, such as temperature, pH, and the presence of other ions or solvents. This compound, with its intricate structure, presents unique solubility characteristics:

  • Polarity: The presence of both the -NH group and the carboxylic acid functional group in the pyridine structure increases the polarity of the compound, suggesting potential solubility in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds enhances its solubility in water and other polar solvents. The carboxylic acid group, in particular, is known for its hydrogen-bonding capabilities.
  • pH Dependence: The solubility may vary significantly with changes in pH; in acidic conditions, the carboxylic group may remain protonated, which could affect solubility negatively.
  • Solvent Choice: Organic solvents like ethanol and methanol may improve the solubility of this compound compared to non-polar solvents, given its functional groups.

In practice, the precise solubility of this compound should be determined experimentally, as it can be highly variable. Significant findings include:

  • Aqueous solubility tends to be higher than non-aqueous due to the ability to interact with water molecules.
  • Temperature increases may enhance solubility, yet specific thresholds can markedly alter outcomes.

In summary, the solubility of 2-(3-chloro-2-methyl-anilino)pyridine-3-carboxylic acid is not only a function of molecular characteristics but also heavily dependent on external conditions, showcasing the fascinating interplay between chemical structure and solubility behaviors.

Interesting facts

Interesting Facts About 2-(3-chloro-2-methyl-anilino)pyridine-3-carboxylic Acid

2-(3-chloro-2-methyl-anilino)pyridine-3-carboxylic acid is a fascinating compound that has attracted the attention of chemists and researchers alike. Below are some key points that highlight its importance and intriguing aspects:

1. Chemical Structure

This compound features a pyridine ring with a carboxylic acid functional group, which plays a vital role in its chemical reactivity. The presence of both anilino and chloro groups adds to its complexity and potential for various chemical reactions.

2. Biological Significance

Compounds like 2-(3-chloro-2-methyl-anilino)pyridine-3-carboxylic acid have been studied for their potential pharmaceutical applications. Some of the notable areas include:

  • Antimicrobial Properties: Researchers are interested in compounds with similar structures for their potential ability to combat bacterial infections.
  • Cancer Research: The modifications to the aniline structure can impact its interaction with biological targets involved in cancer pathology.

3. Synthetic Routes

Synthesizing this compound can involve various organic reactions, showcasing the versatility of organic chemistry. Key methods might include:

  • Nucleophilic Substitution: The chlorinated aniline can undergo nucleophilic substitution reactions to introduce or modify groups.
  • Amination Reactions: These play a crucial role in the functionalization of heterocycles, enabling the incorporation of diverse functional groups.

4. Research Applications

Due to its unique functional groups, 2-(3-chloro-2-methyl-anilino)pyridine-3-carboxylic acid is not only significant in the field of medicinal chemistry but also serves as:

  • A Potential Lead Compound: It may serve as a precursor for drug development and further modifications.
  • A Target for Reaction Studies: Chemists often use such compounds to study reaction mechanisms and pathways.

5. Environmental Considerations

With the increasing focus on sustainability, understanding the environmental impact of synthetic compounds is crucial. Researchers engage in studies to evaluate:

  • Toxicity: Determining how compounds behave in biological systems.
  • Biodegradability: Assessing whether they can be broken down into non-toxic products.

In conclusion, 2-(3-chloro-2-methyl-anilino)pyridine-3-carboxylic acid is more than just a chemical entity; it represents the intersection of organic chemistry, biology, and environmental studies. The ongoing research in this area continues to unveil new possibilities for its application, making it an exciting subject for chemists and students alike.

Synonyms
CLONIXIN
17737-65-4
Clonixic acid
Clonixine
Sch 10304
Clonixino
Clonixinum
2-(3-Chloro-o-toluidino)nicotinic acid
2-(3-chloro-2-methylanilino)pyridine-3-carboxylic acid
Sch-10304
2-(3-Chloro-2-methylanilino)nicotinic acid
2-(2'-Methyl-3'-chloro)anilinonicotinic acid
CBA 93626
3-Pyridinecarboxylic acid, 2-[(3-chloro-2-methylphenyl)amino]-
CHEBI:76200
V7DXN0M42R
NSC-335505
DTXSID2046121
3-Pyridinecarboxylic acid, 2-((3-chloro-2-methylphenyl)amino)-
DTXCID0026121
Sch10304
CBA93626
241-730-1
Chlonixin
Deltar
2-((3-Chloro-2-methylphenyl)amino)nicotinic acid
MFCD00864292
Nicotinic acid, 2-(3-chloro-o-toluidino)-
NSC 335505
2-[(3-Chloro-2-methylphenyl)amino]nicotinic Acid
NSC335505
2-(3-chloro-2-methyl-anilino)pyridine-3-carboxylic acid
NCGC00160384-01
2-[(3-chloro-2-methylphenyl)amino]pyridine-3-carboxylic acid
2-(2-Methyl-3-chloroanilino)nicotinic acid
2-(3-Chloro-2-methyl-phenylamino)-nicotinic acid
Clonix
Clonixin [USAN:INN]
Clonixine [INN-French]
Clonixinum [INN-Latin]
Clonixino [INN-Spanish]
SMR000768694
EINECS 241-730-1
UNII-V7DXN0M42R
BRN 0483212
2-[(3-chloro-2-methylphenyl)amino]-3-pyridinecarboxylic acid
6J3
CLONIXIN [USAN]
Clonixin (USAN/INN)
CLONIXIN [INN]
CLONIXIN [MI]
CLONIXIN [MART.]
CLONIXIN [WHO-DD]
5-22-13-00597 (Beilstein Handbook Reference)
MLS001240214
MLS006010083
SCHEMBL121785
orb1302772
Clonixin, >=98% (HPLC)
CHEMBL1332971
SCHEMBL30702579
HMS2231D05
HMS3372P16
HMS5084O15
Tox21_111776
BDBM50201612
s5046
AKOS003188453
AC-1607
CCG-267076
DB09218
KS-5237
NCGC00160384-04
DA-51970
SY053237
CAS-17737-65-4
HY-121235
C2619
CS-0081284
NS00021762
D03555
D97348
SR-01000338177
Q5135028
SR-01000338177-1
2-(3'-chloro-2'-methylanilino)-pyridine-3-carboxylic acid
3-Pyridinecarboxylic acid, {2-[(3-chloro-2-methylphenyl)amino]-}