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2-[3-chloro-4-(1-piperidyl)phenyl]acetic acid

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Identification
Molecular formula
C13H16ClNO2
CAS number
93050-76-5
IUPAC name
2-[3-chloro-4-(1-piperidyl)phenyl]acetic acid
State
State

At room temperature, 2-[3-chloro-4-(1-piperidyl)phenyl]acetic acid is in a solid state. It is stable under normal conditions and commonly encountered as a crystalline powder.

Melting point (Celsius)
92.00
Melting point (Kelvin)
365.15
Boiling point (Celsius)
222.00
Boiling point (Kelvin)
495.15
General information
Molecular weight
267.74g/mol
Molar mass
267.7420g/mol
Density
1.3000g/cm3
Appearence

The compound 2-[3-chloro-4-(1-piperidyl)phenyl]acetic acid typically appears as a white to off-white crystalline powder. The exact appearance can vary based on purity and form, but it generally maintains this solid and crystalline nature.

Comment on solubility

Solubility of 2-[3-chloro-4-(1-piperidyl)phenyl]acetic acid

The solubility of 2-[3-chloro-4-(1-piperidyl)phenyl]acetic acid is an important consideration in its application and efficacy. Here are some key points regarding its solubility:

  • Polar Nature: The compound contains both aromatic and acidic functional groups, which can enhance its solubility in polar solvents.
  • Aqueous Solubility: This compound is expected to exhibit moderate solubility in water due to its acidity and the presence of the piperidyl group, which can form hydrogen bonds.
  • Solvent Variability: Solubility may vary significantly depending on the solvent used; it is likely to dissolve better in organic solvents like ethanol or methanol compared to non-polar solvents.

In summary, while the exact solubility values can be influenced by factors such as temperature and pH, 2-[3-chloro-4-(1-piperidyl)phenyl]acetic acid demonstrates promise for solubility in polar environments, making it a suitable candidate for various chemical applications. Always consider conducting empirical solubility tests for precise understanding and applications.

Interesting facts

Interesting Facts about 2-[3-chloro-4-(1-piperidyl)phenyl]acetic Acid

2-[3-chloro-4-(1-piperidyl)phenyl]acetic acid, often mentioned in the context of medicinal chemistry, has garnered attention due to its intriguing properties and potential applications. Here are some interesting facts about this compound:

  • Pharmaceutical Relevance: This compound is known for its role as a precursor in the synthesis of various pharmaceuticals, particularly in the field of neurology and psychiatry.
  • Structure-Activity Relationship: The incorporation of the 1-piperidyl group enhances its binding affinity to certain receptors, which is crucial in developing drugs aimed at treating mental health disorders.
  • Chlorine's Influence: The presence of the Cl atom in its structure can significantly affect the compound's reactivity and biological activity, making it an essential component in fine-tuning the properties of potential drug candidates.
  • Research Applications: Scientists have investigated this compound for its effectiveness as an anti-inflammatory agent, opening avenues for research into new therapeutic strategies.
  • Multi-functional Use: Beyond its pharmaceutical applications, its unique chemical properties make it a candidate for cross-disciplinary studies, including materials science and organic synthesis.

The exploration of 2-[3-chloro-4-(1-piperidyl)phenyl]acetic acid highlights the importance of chemical structure in influencing biological properties and underscores the critical role of chemistry in advancing medical science. Its study exemplifies the intersection of theoretical knowledge and practical application in the chemical and pharmaceutical sciences.

Synonyms
BRN 1252232
(3-Chloro-4-piperidinophenyl)acetic acid
ACETIC ACID, (3-CHLORO-4-PIPERIDINOPHENYL)-
26586-30-1
DTXSID50181151
5-20-03-00070 (Beilstein Handbook Reference)
RefChem:316202
DTXCID60103642
CHEMBL3251907