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2-(3-chloro-4-propoxyphenyl)ethanehydroxamic acid

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Identification
Molecular formula
C11H14ClNO3
CAS number
205935-67-9
IUPAC name
2-(3-chloro-4-propoxy-phenyl)ethanehydroxamic acid
State
State
The compound is a solid at room temperature.
Melting point (Celsius)
171.00
Melting point (Kelvin)
444.15
Boiling point (Celsius)
342.20
Boiling point (Kelvin)
615.35
General information
Molecular weight
271.69g/mol
Molar mass
271.7480g/mol
Density
1.3000g/cm3
Appearence
The compound is typically in a solid state at room temperature. Its specific appearance such as crystalline structure or color is not commonly detailed in literature, given its specific chemical nature and potential use in specialized applications.
Comment on solubility

Solubility Insights for 2-(3-Chloro-4-propoxy-phenyl)ethanehydroxamic Acid

The solubility of 2-(3-chloro-4-propoxy-phenyl)ethanehydroxamic acid in various solvents can significantly influence its practical applications in the chemical and pharmaceutical fields. Understanding the solubility properties can aid in the optimization of formulations and enhance the efficacy of this compound.

Key Factors Influencing Solubility:

  • Polarity: The presence of hydroxamic acid groups tends to increase polarity, which often enhances solubility in polar solvents such as water.
  • Functional Groups: The substitution of the phenyl ring with a chlorinated alkyl group and a propoxy group can affect solubility through steric hindrance and electronic effects.
  • Hydrogen Bonding: Hydroxamic acids can engage in hydrogen bonding, which may further facilitate solubility in hydrogen-bonding solvents.

It is important to note that solubility may not be uniform across all conditions. Potential variability could arise from:

  • Temperature changes, which generally increase solubility for many compounds.
  • pH levels of the solution, as they might alter the protonation state of the hydroxamic group.
  • The presence of other ions or solutes in solution, which might cause precipitation or complexation.

In summary, the solubility of 2-(3-chloro-4-propoxy-phenyl)ethanehydroxamic acid is a complex interplay of its chemical structure and the environmental conditions. Further experiments and analyses, particularly in various solvent systems, are essential to fully characterize its solubility behavior.

Interesting facts

Interesting Facts about 2-(3-chloro-4-propoxy-phenyl)ethanehydroxamic acid

This intriguing compound, 2-(3-chloro-4-propoxy-phenyl)ethanehydroxamic acid, falls under the category of hydroxamic acids, which are known for their diverse biological activities. Here are some fascinating insights:

  • Biological Significance: Hydroxamic acids are notable for their ability to inhibit various enzymes, including metalloproteinases and histone deacetylases, which play vital roles in cell signaling and gene regulation.
  • Pharmaceutical Potential: Compounds similar to this one have been researched for their anticancer and anti-inflammatory properties, making them of significant interest in drug development.
  • Synthetic Versatility: The synthesis of hydroxamic acids, including this particular compound, often involves the reaction of carboxylic acids with hydroxylamine, showcasing the synthetic versatility and wide applicability in organic chemistry.
  • Functional Group Properties: The hydroxamic acid functional group is characterized by its ability to form coordination complexes with metal ions, which has implications for medicinal chemistry and catalysis.

Researchers are continually exploring the functional attributes and therapeutic potentials of compounds like 2-(3-chloro-4-propoxy-phenyl)ethanehydroxamic acid. According to a study published in the Journal of Medicinal Chemistry, “The unique combination of structural features allows for targeted pharmacological activity against critical disease pathways.” This statement emphasizes the relevance of such compounds in the ongoing quest for effective treatments.

In conclusion, 2-(3-chloro-4-propoxy-phenyl)ethanehydroxamic acid exemplifies the intersection of organic chemistry and pharmaceutical innovation, warranting further investigation to unlock its full potential.

Synonyms
23142-40-7
2-(3-Chloro-4-propoxyphenyl)acetohydroxamic acid
ACETOHYDROXAMIC ACID, 2-(3-CHLORO-4-PROPOXYPHENYL)-
DTXSID30177719
RefChem:316780
DTXCID40100210
2-(3-chloro-4-propoxyphenyl)-N-hydroxyacetamide