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Thioflavin T

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Identification
Molecular formula
C17H19ClN2PS2
CAS number
2390-54-7
IUPAC name
2-[3-chloro-5-(1-ethylbenzo[e][1,3]benzothiazol-1-ium-2-yl)penta-2,4-dienylidene]-1-ethyl-benzo[e][1,3]benzothiazole;iodide
State
State

At room temperature, Thioflavin T is typically found as a solid.

Melting point (Celsius)
199.80
Melting point (Kelvin)
472.95
Boiling point (Celsius)
244.00
Boiling point (Kelvin)
517.15
General information
Molecular weight
480.00g/mol
Molar mass
480.0020g/mol
Density
1.2370g/cm3
Appearence

Thioflavin T appears as a yellow or yellow-green crystalline powder. It is a fluorescent dye that emits blue fluorescence when bound to amyloid fibrils. The compound is widely used in histochemistry to stain amyloid plaques and fibrils for research.

Comment on solubility

Solubility of 2-[3-chloro-5-(1-ethylbenzo&e[1,3]benzothiazol-1-ium-2-yl)penta-2,4-dienylidene]-1-ethyl-benzo[e][1,3]benzothiazole; iodide

The solubility of complex compounds like 2-[3-chloro-5-(1-ethylbenzo[e][1,3]benzothiazol-1-ium-2-yl)penta-2,4-dienylidene]-1-ethyl-benzo[e][1,3]benzothiazole; iodide is influenced by various factors, including its structure and the presence of functional groups. This particular compound contains both organic and ionic features, which can affect its solubility behavior in different solvents.

Factors Influencing Solubility:

  • Ionic Interactions: The iodide component suggests potential solubility in polar solvents, as ionic compounds typically exhibit higher solubility in water.
  • Hydrophobic Regions: The ethyl and benzo derivatives may impart hydrophobic characteristics, possibly limiting solubility in water but enhancing solubility in organic solvents.
  • Temperature and pH: As with many chemical compounds, changes in temperature and pH can significantly alter solubility; higher temperatures often increase solubility for solids.

Moreover, it is important to consider that solubility may vary dramatically among different solvents, which can be categorized as:

  1. Polar Solvents: Such as water, where ionic components generally dissolve well.
  2. Non-polar Solvents: Such as hexane, where organic sections might exhibit greater solubility due to similar interactions.

In conclusion, while 2-[3-chloro-5-(1-ethylbenzo[e][1,3]benzothiazol-1-ium-2-yl)penta-2,4-dienylidene]-1-ethyl-benzo[e][1,3]benzothiazole; iodide has the potential for solubility in specific environments, predicting its exact behavior requires a thorough understanding of the solvent characteristics and the interaction mechanisms at play.

Interesting facts

Interesting Facts about 2-[3-Chloro-5-(1-ethylbenzo[e][1,3]benzothiazol-1-ium-2-yl)penta-2,4-dienylidene]-1-ethyl-benzo[e][1,3]benzothiazole; iodide

This compound, with its complex structure and intriguing properties, belongs to the realm of benzothiazole derivatives, which are known for their wide variety of applications in both biological and material sciences. Here are some noteworthy aspects:

  • Unique Structure: The compound features a remarkable blend of benzothiazole moieties, chloro groups, and ethyl substituents, providing it with a distinctive chemical identity that sets it apart from simpler organic compounds.
  • Biological Relevance: Compounds containing benzothiazole scaffolds have shown potential in medicinal chemistry, often exhibiting anti-cancer, antimicrobial, and anti-inflammatory activities.
  • Photophysical Properties: The presence of the penta-2,4-dienylidene group may contribute to unique photophysical characteristics, such as enhanced fluorescence, making it of interest in studies pertaining to organic light-emitting diodes (OLEDs) and sensors.
  • Versatile Applications: Due to its structure, this compound could serve as a dye or pigment, with potential applications in cosmetics, textiles, or even biological imaging.
  • Research Interest: Scientists are continually researching new derivatives of benzothiazoles, making compounds like this one prominent in studies aimed at developing novel drugs or improving existing materials.

As emphasized by one researcher, "The exploration of benzothiazole derivatives opens up new avenues in drug development and materials science." This compound is a testament to the innovative possibilities that exist within the world of organic chemistry. Its synthesis and characterization can be a fascinating journey for both chemistry students and seasoned scientists alike.

Synonyms
2-[3-Chloro-5-(1-ethylnaphtho[1,2-d][1,3]thiazol-2(1H)-ylidene)penta-1,3-dien-1-yl]-1-ethylnaphtho[1,2-d][1,3]thiazol-1-ium iodide
DTXSID70942887