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Clomipramine

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Identification
Molecular formula
C19H23ClN2O
CAS number
303-49-1
IUPAC name
2-[(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)oxy]-N,N-dimethyl-ethanamine
State
State

Clomipramine is usually in a solid state at room temperature.

Melting point (Celsius)
192.00
Melting point (Kelvin)
465.15
Boiling point (Celsius)
426.40
Boiling point (Kelvin)
699.60
General information
Molecular weight
314.86g/mol
Molar mass
314.8370g/mol
Density
1.2000g/cm3
Appearence

Clomipramine typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-[(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)oxy]-N,N-dimethyl-ethanamine

The solubility of the compound 2-[(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)oxy]-N,N-dimethyl-ethanamine can be influenced by various factors, including its molecular structure and the environmental conditions. Solubility is a crucial property as it determines how effectively a compound can interact with biological systems, solvents, and reactants. Here are some key points to consider:

  • Polarity: The presence of the aromatic rings and ether functionality may suggest some degree of non-polar characteristics, potentially reducing solubility in polar solvents. Conversely, the ammonium group can enhance solubility in polar environments.
  • Solvent Interaction: This compound might demonstrate variability in solubility across different solvents, particularly exhibiting enhanced solubility in organic solvents compared to water.
  • Temperature Effect: Solubility can increase with rising temperature, revealing more about the thermodynamic stability of the solute in solutions.
  • pH Sensitivity: Due to the presence of amine groups, the solubility may also be significantly affected by pH, influencing protonation states and ionic forms.

In summary, the solubility of this compound is a complex characteristic shaped by molecular structure and environmental conditions. As such, thorough experimental solubility testing is essential to understand its behavior in various applications.

Interesting facts

Interesting Facts about 2-[(3-chloro-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)oxy]-N,N-dimethyl-ethanamine

This intriguing compound is notable for its potential applications in medicinal chemistry and neuroscience. Often classified as a therapeutic agent, it belongs to a category of compounds that exhibit neuroprotective properties, making it a subject of interest for studies in treating neurodegenerative diseases.

Here are some compelling points about this compound:

  • Structural Complexity: The chemical structure is quite complex, featuring a benzothiepin moiety, which is known for its diverse biological activity. This complexity often correlates with unique electronic and steric properties, which can influence how the compound interacts with biological targets.
  • Pharmacological Potential: Research indicates this compound may play a role in modulating neurotransmitter systems in the brain, potentially offering therapeutic benefits for conditions such as depression and anxiety.
  • Chloro Substitution: The presence of a chlorine atom in the structure can enhance the lipophilicity of the compound, allowing it to cross the blood-brain barrier more effectively, which is a crucial factor in neuropharmacology.
  • Dimethylamine Moiety: The N,N-dimethyl-ethanamine part of the compound is significant for its ability to mimic neurotransmitters, making it a potentially valuable candidate for developing new drugs that target synaptic transmission.
  • Research Outlook: Ongoing studies aim to unravel the full spectrum of this compound's biological activity and therapeutic potential, focusing on aspects like its efficacy, safety profiles, and mechanism of action.

As research progresses, compounds like this one that combine structural complexity with promising pharmacological properties could lead to novel treatment strategies and enhance our understanding of biochemical interactions in the human body.

Synonyms
AKOS005065579