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Chlorphenamine

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Identification
Molecular formula
C16H19ClN2S
CAS number
132-22-9
IUPAC name
2-[(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)sulfanyl]-N,N-diethyl-ethanamine
State
State

At room temperature, chlorphenamine is typically a solid. It is usually encountered in the form of its maleate salt, which helps increase its water solubility for pharmaceutical uses. In its free base form, it might be a little waxy or oily.

Melting point (Celsius)
78.00
Melting point (Kelvin)
351.15
Boiling point (Celsius)
360.00
Boiling point (Kelvin)
633.15
General information
Molecular weight
274.85g/mol
Molar mass
274.8460g/mol
Density
1.1215g/cm3
Appearence

Chlorphenamine, commonly found as chlorpheniramine maleate, usually appears as a white crystalline solid. It is odorless and can also be found in powder form. It is known for its stability when exposed to air and its ability to dissolve in water, albeit not very easily. Under various lighting conditions, its crystalline structure can reflect light, contributing to its shiny appearance.

Comment on solubility

Solubility of 2-[(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)sulfanyl]-N,N-diethyl-ethanamine

The solubility of this compound, often referred to as a complex organosulfur amine, can be influenced by several factors including its molecular structure, polarity, and the nature of the solvent. Here are some key points regarding its solubility:

  • Polarity: The presence of the sulfanyl group (–S–) and the amine functional groups (–NH and –N–) in the compound increases its polarity. This may enhance its solubility in polar solvents.
  • Solvent Compatibility: It is likely to be more soluble in polar organic solvents (such as ethanol or methanol) compared to non-polar solvents, due to its polar characteristics.
  • Hydrogen Bonding: The amine group can participate in hydrogen bonding, potentially increasing solubility in water. However, steric hindrance from the bulky cyclic structure may limit this interaction.
  • Temperature Effects: Typically, solubility increases with temperature; hence, heating may aid in dissolving this compound in suitable solvents.

In summary, while the solubility of 2-[(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)sulfanyl]-N,N-diethyl-ethanamine may be favorable in certain polar environments, its complex structure suggests that empirical testing is essential to determine its specific solubility characteristics accurately.

Interesting facts

Interesting Facts about 2-[(3-Chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-11-yl)sulfanyl]-N,N-diethyl-ethanamine

This intriguing compound belongs to the class of organic chemicals recognized for their diverse biological activities. One of the most notable aspects of this compound is its unique structure, featuring a complex bicyclic system which enhances its potential interaction with biological targets.

Potential Applications

  • Pharmaceutical Development: Due to its structural characteristics, the compound may be researched for its pharmacological properties, particularly in the fields of neurology and psychiatry.
  • Antimicrobial Properties: Compounds with similar structures often exhibit antimicrobial effects, making them candidates for further studies in drug formulation.
  • Research in Organic Chemistry: This compound serves as an example of how variations in molecular structure can lead to different functional properties. This provides a valuable teaching tool for students.

Structural Significance

The presence of the cyclohepta framework contributes to the compound's rigidity and stereochemistry, which can be pivotal in determining its biological interactions. The sulfanyl group likely plays a critical role in modulating its reactivity and overall functionality.

Quote from Research

As noted by scientists, "The intricacies of molecular design can reveal untapped therapeutic potentials, opening doors for novel treatment strategies." This rings particularly true for compounds like this one, which possess the ability to engage complex biological systems.

Conclusion

The exploration of this compound underscores the intersection of chemistry and biology, illustrating how the subtle changes in molecular structure can lead to significant variations in activity and application. Researchers continue to delve into such compounds, inspired by the boundless possibilities they embody.