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Cyclizine Hydrochloride

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Identification
Molecular formula
C20H25ClN2O2Cl2
CAS number
303-25-3
IUPAC name
2-[(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium;dichloride
State
State

At room temperature, Cyclizine hydrochloride is in the solid state. It is usually formulated into tablets for oral administration or solutions for injection in clinical settings.

Melting point (Celsius)
194.00
Melting point (Kelvin)
467.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
475.86g/mol
Molar mass
475.8560g/mol
Density
1.1000g/cm3
Appearence

Cyclizine hydrochloride typically appears as a white or almost white crystalline powder. It is highly soluble in water, aiding its administration in various pharmaceutical formulations.

Comment on solubility

Solubility of 2-[(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium;dichloride

The solubility of the compound 2-[(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium;dichloride can be influenced by several factors:

  • Polarity: As a quaternary ammonium compound, it exhibits polar characteristics, potentially enhancing its solubility in polar solvents like water.
  • Salt Formation: Being a dichloride, the ionic nature from chloride ions typically increases solubility in aqueous solutions.
  • Temperature: Increased temperature may improve solubility, allowing for better dissolution rates.

In general, the cationic nature of quaternary ammonium compounds, along with the presence of halide counterions, often leads to a higher affinity for solvation in water. However, to ascertain specific solubility values, experimental data would be essential, as various conditions can notably affect the dissolution process.

In summary, the solubility profile of this compound seems promising in polar solvents due to its structural features and ionic composition, though empirical testing is crucial for a definitive understanding.

Interesting facts

Interesting Facts About 2-[(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium; dichloride

This intriguing compound represents a unique class of quaternary ammonium salts, which are often known for their wide-ranging applications in various fields. Here are some fascinating aspects of this particular compound:

  • Quaternary Ammonium Structure: Quaternary ammonium salts are characterized by the presence of a positively charged nitrogen atom bonded to four organic groups. This structural feature imparts several important properties, such as antimicrobial activity and surfactant behavior.
  • Biological Relevance: Given its complex structure, this compound may exhibit interesting biological properties. Compounds similar to quaternary ammonium salts are frequently investigated for use in pharmaceuticals, antimicrobial agents, and biocides, making them significant in medical and industrial applications.
  • Solubility and Interactions: While the solubility may vary, quaternary ammonium compounds generally show good solubility in polar solvents, making them versatile in formulations. Their ability to interact with biological membranes can affect their function as drug carriers or therapeutic agents.
  • Potential Applications: The structural features of this compound hint at potential applications in drug development, chemical biology, or as a specialized surfactant. Compounds like it are often explored for their roles in creating stable emulsions, coatings, and disinfectants.
  • Chirality and Isomers: The presence of chiral centers in such compounds can lead to the formation of different isomers, which may exhibit significantly different biological activities. Understanding stereochemistry is crucial for optimizing their efficacy in medicinal chemistry.

In summary, the compound 2-[(3-chloro-7,8,9,10-tetrahydro-6H-cyclohepta[b]quinolin-5-ium-11-yl)oxy]propyl-dimethyl-ammonium; dichloride stands out due to its structural complexity and potential utility in various scientific domains. Ongoing research continues to uncover its unique properties and applications, centering on its role in improving human health and industrial processes.

Synonyms
5231-44-7
6H-Cyclohepta(b)quinoline, 3-chloro-11-(2-(dimethylamino)-1-methylethoxy)-7,8,9,10-tetrahydro-, dihydrochloride
6H-Cyclohepta(b)quinoline, 3-chloro-11-(2-(dimethylamino)-1-methylethoxy)- 7,8,9,10-tetrahydro-, dihydrochloride