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Amitriptyline

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Identification
Molecular formula
C20H23NO
CAS number
50-48-6
IUPAC name
2-[3-(dimethylamino)-2-methyl-propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ol
State
State

Amitriptyline is typically found in solid state at room temperature.

Melting point (Celsius)
196.00
Melting point (Kelvin)
469.15
Boiling point (Celsius)
351.48
Boiling point (Kelvin)
624.63
General information
Molecular weight
277.40g/mol
Molar mass
277.4000g/mol
Density
1.0360g/cm3
Appearence

Amitriptyline is a white to off-white, odorless crystalline powder. It is often found in its hydrochloride salt form for medical use, which is usually a white or slightly yellow powder.

Comment on solubility

Solubility of 2-[3-(dimethylamino)-2-methyl-propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ol

The compound 2-[3-(dimethylamino)-2-methyl-propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ol exhibits unique solubility characteristics due to its complex structure. Understanding its solubility is crucial for applications in various fields, including pharmaceuticals and organic synthesis. Here are key points to consider:

  • Polarity: The presence of polar functional groups, such as the hydroxyl group, influences solubility in polar solvents like water.
  • Hydrophobic regions: The tricyclic backbone and alkyl side chains contribute to hydrophobic interactions, suggesting limited solubility in water but enhanced solubility in organic solvents such as methanol or ethanol.
  • Interactions with solvents: In polar solvents, the compound may form hydrogen bonds, enhancing solubility despite its hydrophobic characteristics.
  • Concentration effects: As with many complex organic compounds, solubility can vary significantly with concentration, which can lead to saturation effects in solution.

In summary, while this compound shows potential solubility in various solvents, the degree of solubility is highly dependent on factors like solvent choice, temperature, and concentration. As a rule of thumb, “like dissolves like”—making organic solvents more favorable for dissolving this compound compared to aqueous environments.

Interesting facts

Exploring 2-[3-(dimethylamino)-2-methyl-propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ol

This intriguing compound, known for its complex structure and unique properties, showcases the marvelous intricacies of organic chemistry. Here are some fascinating aspects of this chemical:

  • Structural Uniqueness: With its tricyclic framework, this compound exemplifies the beauty of cyclic organic molecules, allowing for multiple stereochemical configurations.
  • Functional Groups: The presence of the dimethylamino group plays a crucial role in the compound's reactivity, making it an interesting subject for pharmacological studies and potential therapeutic applications.
  • Applications: Compounds like this often find their use in the development of pharmaceuticals, especially in the field of neuropharmacology, where they can influence neurotransmitter pathways.
  • Research Potential: The unique properties stemming from its tricyclic structure present ample opportunities for researchers to explore new synthetic routes or unravel mechanisms relevant in medicinal chemistry.
  • Chemical Stability: Examining the stability of such compounds under various conditions can provide insight into their applicability in different environments, particularly in drug formulation.

As echoed in the words of renowned chemist Marie Curie, "In science, we must be interested in things rather than in persons." The study of this compound exemplifies the essence of science, where the focus on molecular interactions and functionalities opens doors to innovations and discoveries that might significantly impact human health and technology.

This compound, with its rich structure and diverse implications, remains a captivating subject for both budding chemistry students and seasoned scientists alike.

Synonyms
BRN 2153820
2625-17-4
10,11-Dihydro-5-(3-dimethylamino-2-methylpropyl)-5H-dibenzo(a,d)cyclohepten-5-ol
5H-Dibenzo(a,d)cyclohepten-5-ol, 10,11-dihydro-5-(3-dimethylamino-2-methylpropyl)-
5H-Dibenzo(a,d)cyclohepten-5-ol, 5-(3-(dimethylamino)-2-methylpropyl)-10,11-dihydro-
DTXSID10863002
GFTHYQRJEOORHK-UHFFFAOYSA-N
5-[3-(Dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ol