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Amitriptylinoxide

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Identification
Molecular formula
C20H25NO
CAS number
2137-18-0
IUPAC name
2-[3-(dimethylamino)propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ol
State
State

At room temperature, Amitriptylinoxide is usually found in a solid crystalline form.

Melting point (Celsius)
179.00
Melting point (Kelvin)
452.15
Boiling point (Celsius)
435.80
Boiling point (Kelvin)
708.95
General information
Molecular weight
311.43g/mol
Molar mass
311.4330g/mol
Density
1.1360g/cm3
Appearence

Amitriptylinoxide is typically found as a crystalline powder. It may appear white or off-white in color, maintaining a semi-solid state under certain conditions.

Comment on solubility

Solubility of 2-[3-(dimethylamino)propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ol

The solubility of 2-[3-(dimethylamino)propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ol can be influenced by various factors, leading to some intriguing aspects:

  • Polarity: Given the presence of a dimethylamino group, which is polar, the compound may exhibit solubility in polar solvents.
  • Hydrogen bonding: The hydroxyl (-OH) group in the compound suggests potential for hydrogen bonding, enhancing solubility in water.
  • Hydrophobic characteristics: The tricyclic structure and multiple unsaturated bonds can contribute to hydrophobic interactions, potentially limiting solubility in aqueous environments.
  • Solvent choice: It could be more soluble in organic solvents like ethanol, methanol, or dimethyl sulfoxide (DMSO), which can accommodate both polar and nonpolar regions.

As is often stated, "Solubility is a compound's ability to dissolve in a solvent," and for this compound, the balance between its polar and nonpolar features plays a critical role in determining its fate in various environments.
Understanding the solubility profile can be crucial for applications in pharmaceuticals and material sciences, where the interaction between the drug and its medium can determine efficacy and stability.

Interesting facts

Exploring 2-[3-(dimethylamino)propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ol

This intriguing compound is often of interest to chemists due to its unique structural features and potential applications. Below are some fascinating points about this compound:

  • Complex Structure: The compound features a tricyclic structure combined with multiple double bonds, illustrating the beauty of chemical architecture.
  • Biological Relevance: Compounds similar to this one are often explored for their effects on biological systems, particularly in the realm of drug design and development.
  • Dimethylamino Group: The presence of a dimethylamino group enhances its solubility and can significantly influence its pharmacological properties.
  • Synthesis Potential: The compound's intricate framework suggests interesting synthetic pathways, which can be explored for educational purposes in organic chemistry labs.
  • Research Implications: Research involving this compound could lead to innovative findings in medicinal chemistry or material science, highlighting its versatility.

With its multifaceted characteristics, 2-[3-(dimethylamino)propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ol serves as a fantastic example of how chemistry intertwines structure with function. As quoted in the field, "The more complex the structure, the more potential for discovery." This compound is certainly one that captivates the imagination of both students and chemists alike.

Synonyms
1159-03-1
Amitriptynol
5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ol
5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol
EINECS 214-594-6
67H6DX3NOO
BRN 2148173
5-(3-Dimethylaminopropyl)5-dibenzo(a,d)cycloheptadienol
5-(3-Dimethylaminopropyl)-10,11-dihydrodibenzo[a,d]cyclohepten-5-ol
10,11-Dihydro-5-(3-dimethylaminopropyl)-5H-dibenzo(a,d)cyclohepten-5-ol
5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ol
5H-DIBENZO(a,d)CYCLOHEPTEN-5-OL, 10,11-DIHYDRO-5-(3-DIMETHYLAMINOPROPYL)-
5H-Dibenzo(a,d)cyclohepten-5-ol, 5-(3-(dimethylamino)propyl)-10,11-dihydro-
5H-Dibenzo[a,d]cyclohepten-5-ol, 5-[3-(dimethylamino)propyl]-10,11-dihydro-
DTXSID10151214
EC 214-594-6
5-(3-Dimethylaminopropyl)-10,11-dihydrodibenzo(a,d)cyclohepten-5-ol
AMITRIPTYLINE HYDROCHLORIDE IMPURITY D [EP IMPURITY]
NORTRIPTYLINE HYDROCHLORIDE IMPURITY D [EP IMPURITY]
5-(3-(DIMETHYLAMINO)PROPYL)-10,11-DIHYDRO-5H-DIBENZO(A,D)(7)ANNULEN-5-OL
5-(3-(DIMETHYLAMINO)PROPYL)-10,11-DIHYDRO-5H-DIBENZO(A,D)-CYCLOHEPTEN-5-OL
AMITRIPTYLINE HYDROCHLORIDE IMPURITY D (EP IMPURITY)
NORTRIPTYLINE HYDROCHLORIDE IMPURITY D (EP IMPURITY)
5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ol
5H-Dibenzo[a,d]cyclohepten-5-ol, 10,11-dihydro-5-(3-dimethylaminopropyl)-
DTXCID9073705
Amitriptyline Impurity B
2-[3-(dimethylamino)propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ol
5-(3-DIMETHYLAMINOPROPYL)-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-OL
UNII-67H6DX3NOO
MFCD00569159
Oprea1_247281
Oprea1_843827
CBDivE_012358
MLS000689024
CHEMBL1564657
SCHEMBL11252431
HMS1683L02
HMS2651H03
STK192083
AKOS000512692
AC-7643
FD22331
NCGC00245055-01
PD013717
SMR000286249
CS-0329516
NS00006670
G68798
AG-690/11629173
Q27264131
11-[3-(dimethylamino)propyl]-5,6-dihydrodibenzo[1,2-a:1\',2\'-e][7]annulen-11-ol
5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenzo-[a,d]cyclohepten-5-ol
5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol #
2-[3-(dimethylamino)propyl]tricyclo[9.4.0.0^{3,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ol