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Amitriptyline

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Identification
Molecular formula
C20H23N
CAS number
50-48-6
IUPAC name
2-[3-(dimethylamino)propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carbonitrile
State
State

At room temperature, amitriptyline is typically in the form of a solid as a hydrochloride salt. This state makes it suitable for its most common use as an oral tablet in medical prescriptions.

Melting point (Celsius)
196.00
Melting point (Kelvin)
469.00
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.00
General information
Molecular weight
313.86g/mol
Molar mass
313.8650g/mol
Density
1.1800g/cm3
Appearence

Amitriptyline is typically found in the form of a white, odorless crystalline powder. It is often prepared as a hydrochloride salt for its increased solubility in water and other solvents, making it easier to use in pharmaceutical formulations. The powder has a slight bitter taste.

Comment on solubility

Solubility of 2-[3-(dimethylamino)propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carbonitrile

The solubility of 2-[3-(dimethylamino)propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carbonitrile can be quite complex due to its unique structural features. Here are some key points regarding its solubility:

  • Solvent Dependence: The solubility of this compound is likely to be influenced by the choice of solvent. Polar solvents may interact more favorably with the dimethylamino group, enhancing solubility.
  • Hydrophobic Interactions: Given the presence of large cyclic structures and multiple double bonds, it is reasonable to expect significant hydrophobic interactions, which might limit solubility in aqueous environments.
  • Temperature Factor: As with many organic compounds, solubility can increase with temperature. Higher temperatures may lead to greater molecular movement and solvation.
  • pH Sensitivity: The basic nature of the dimethylamino group could result in pH-dependent solubility, making it more soluble in basic conditions, while less soluble in acidic environments.

In conclusion, the solubility profile of this compound is *likely to be variable*, depending on the solvent, temperature, and pH conditions applied. Understanding these factors is crucial for applications in chemical synthesis and material science.

Interesting facts

Interesting Facts about 2-[3-(dimethylamino)propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carbonitrile

This compound is a fascinating example of organic chemistry, exhibiting unique structural and functional properties. Its complex arrangement of atoms and multiple functional groups make it particularly interesting to study.

Key Features:

  • Tricyclic Structure: The compound features a tricyclic framework that contributes to its stability and potential reactivity.
  • Dimethylamino Group: The presence of a dimethylamino group enhances its ability to interact with biological systems, which could make it a candidate for pharmaceutical applications.
  • Cyanide Functionality: The carbonitrile group (–C≡N) adds a level of polarity and may facilitate new chemical reactions, making it an intriguing subject for further exploration.

The structure of this compound is characterized by its interesting polycyclic arrangement and extended π-conjugation, which may impart valuable electronic properties. As a student or researcher, one might appreciate the compound’s potential in applications such as:

  1. Drug Design
  2. Photochemical Studies
  3. Material Science

"The diversity in molecular architecture leads to endless possibilities in chemical functionality!" This saying resonates well when discussing compounds like this, as it embodies the heart of chemical innovation.

In summary, 2-[3-(dimethylamino)propyl]tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carbonitrile serves as an intriguing platform for the study of complex organic interactions, showcasing the beauty and depth of chemical science.