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Etodolac

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Identification
Molecular formula
C17H21NO3
CAS number
41340-25-4
IUPAC name
2-[(3-ethoxy-1-methyl-3-oxo-prop-1-enyl)amino]-2-phenyl-acetic acid
State
State

At room temperature, Etodolac is in a solid state, existing as a crystalline powder.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.00
Boiling point (Celsius)
361.00
Boiling point (Kelvin)
634.00
General information
Molecular weight
287.36g/mol
Molar mass
287.3530g/mol
Density
1.2150g/cm3
Appearence

Etodolac appears as a white to off-white crystalline powder. It is practically odorless.

Comment on solubility

Solubility of 2-[(3-ethoxy-1-methyl-3-oxo-prop-1-enyl)amino]-2-phenyl-acetic acid

The solubility of 2-[(3-ethoxy-1-methyl-3-oxo-prop-1-enyl)amino]-2-phenyl-acetic acid can be influenced by various factors, including its molecular structure and the presence of functional groups. Analyzing this compound, we can make the following observations:

  • Hydrophilicity vs. Hydrophobicity: The presence of the ethoxy and phenyl groups introduces both hydrophobic and hydrophilic characteristics, potentially leading to variable solubility in different solvents.
  • Solvent Interaction: This compound is more likely to be soluble in polar solvents due to the potential for hydrogen bonding with the carboxylic acid group, while it may be less soluble in nonpolar solvents.
  • pH Dependence: The solubility of this compound can also be affected by the pH of the solution. Acidic environments may enhance solubility due to the deprotonation of the carboxylic acid group.
  • Temperature Effects: Increasing the temperature generally increases the solubility of many organic compounds; thus, we could expect varying solubility at different temperatures.

In conclusion, while the solubility of 2-[(3-ethoxy-1-methyl-3-oxo-prop-1-enyl)amino]-2-phenyl-acetic acid is not universal and can exhibit dependence on the solvent used and environmental conditions, its detailed characterization in specific solvents is essential for practical applications. As noted, "the behavior of chemical compounds in solutions can expand significantly in complex mixtures."

Interesting facts

Interesting Facts about 2-[(3-ethoxy-1-methyl-3-oxo-prop-1-enyl)amino]-2-phenyl-acetic acid

2-[(3-ethoxy-1-methyl-3-oxo-prop-1-enyl)amino]-2-phenyl-acetic acid is a notable compound in the field of organic chemistry, primarily due to its unique structure and potential applications. Here are some intriguing points about this compound:

  • Synthetic Versatility: This compound features a complex core structure, exhibiting unique functional groups that can be transformed to create a variety of derivatives. This makes it valuable in synthetic chemistry.
  • Biological Significance: Preliminary studies suggest that this compound may have biological activity, opening avenues for research in pharmaceuticals, particularly in drug design for various diseases.
  • Structure-Activity Relationship (SAR): The presence of the ethoxy and phenyl groups suggests that the compound may interact effectively with biological targets, making it a candidate for SAR studies.
  • Teaching Opportunities: For students in organic chemistry, the study of this compound can provide insight into amino acid derivatives and the intricacies of multi-functionalized organic molecules.

Moreover, the compound's combination of an alkene and an acid highlights the importance of reactivity in organic synthesis. Analyzing the stereochemistry and potential resonance structures can lead to rich discussions surrounding electrophiles and nucleophiles in reaction mechanisms.

In summary, 2-[(3-ethoxy-1-methyl-3-oxo-prop-1-enyl)amino]-2-phenyl-acetic acid is more than just a name; it embodies a plethora of opportunities for exploration and scientific discovery in both academic and practical realms.

Synonyms
SCHEMBL8680909