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Iopromide

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Identification
Molecular formula
C18H24I3N3O8
CAS number
73334-07-3
IUPAC name
2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]-2-phenyl-acetic acid
State
State

At room temperature, iopromide is typically encountered in a solid crystalline state when pure. However, it is often used in solution form as a contrast agent in medical imaging.

Melting point (Celsius)
118.00
Melting point (Kelvin)
391.15
Boiling point (Celsius)
412.70
Boiling point (Kelvin)
685.85
General information
Molecular weight
791.12g/mol
Molar mass
791.1230g/mol
Density
1.4300g/cm3
Appearence

Iopromide is an off-white to pale yellow crystalline powder. It may also appear as a colourless, clear solution when dissolved in water for pharmaceutical preparations.

Comment on solubility

Solubility of 2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]-2-phenyl-acetic acid

The solubility of 2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]-2-phenyl-acetic acid is an intriguing topic due to its complex structure which influences its behavior in various solvents. Here are some key points to consider:

  • Structural Impact: The presence of multiple **iodine** atoms in the compound significantly affects its polarity and, consequently, its solubility in organic solvents.
  • Solvent Selectivity: This compound is expected to demonstrate solubility in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol, while having limited solubility in polar solvents like water.
  • pH Dependence: The solubility may also vary with pH due to the presence of the carboxylic acid functional group, which can dissociate to form anionic species, enhancing its solubility in basic solutions.
  • Temperature Effects: Elevated temperatures are likely to increase solubility, particularly in organic solvents, as thermal energy can assist in breaking intermolecular interactions.

In summary, understanding the solubility of this compound requires considering its unique structural features and how these interact with different solvents. As the saying goes, "Like dissolves like," meaning that similar properties between solute and solvent enhance solubility.

Interesting facts

Interesting Facts about 2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]-2-phenyl-acetic acid

This intriguing compound exhibits a complex structure that makes it a subject of interest in the field of pharmaceutical chemistry. The presence of multiple functional groups contributes to its unique chemical properties and potential applications.

  • Biological Significance: This compound has been studied for its potential biological activities. The triiodo-phenoxy moiety, for instance, suggests possible interactions with thyroid hormones, making it worth exploring for hormonal regulation.
  • Diverse Applications: The various functional groups can allow this compound to serve multiple purposes, from being a potential drug candidate to a useful intermediate in organic synthesis.
  • Design and Synthesis: The synthesis of such a multi-functional molecule can be intricate. Chemists must use strategic planning to efficiently assemble the different components while considering factors like yield and purity.
  • Toxicology Studies: As with any compound containing iodine, toxicology assessments are vital for understanding the safety profile. Iodine-laden compounds can display unique metabolic pathways, necessitating thorough study.

As noted by chemists, “The complexity of molecular architecture often predicts the diversity of biological effects.” This makes 2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]-2-phenyl-acetic acid not only a compound of synthetical interest but also a vital piece in the larger puzzle of medicinal chemistry.

In conclusion, this compound exemplifies how intricate chemical structures can lead to numerous possibilities in research and application, opening avenues for discovery in pharmacology and beyond.

Synonyms
23189-39-1
BRN 2915932
2-(3-(N-Ethylpropionamido)-2,4,6-triiodophenoxy)-2-phenylacetic acid
Acido (3-N-etilpropionilamino-2,4,6-triiodofenossi)fenilacetico [Italian]
ACETIC ACID, 2-(3-(N-ETHYLPROPIONAMIDO)-2,4,6-TRIIODOPHENOXY)-2-PHENYL-
Benzeneacetic acid, alpha-(3-(ethyl-(1-oxopropyl)amino)-2,4,6-triiodophenoxy)-
Acido (3-N-etilpropionilamino-2,4,6-triiodofenossi)fenilacetico
RefChem:316441
Benzeneacetic acid, alpha-(3-(ethyl-(1-oxopropyl)amino)-2,4,6-triiodophenoxy)-(9CI)
DTXSID40945860
2-[3-(N-Ethylpropionylamino)-2,4,6-triiodophenoxy]-2-phenylacetic acid
{3-[Ethyl(propanoyl)amino]-2,4,6-triiodophenoxy}(phenyl)acetic acid