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Iopamidol

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Identification
Molecular formula
C17H22I3N3O8
CAS number
60166-93-0
IUPAC name
2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]hexanoic acid
State
State
At room temperature, Iopamidol is typically in a solid, crystalline state with a white appearance.
Melting point (Celsius)
267.00
Melting point (Kelvin)
540.20
Boiling point (Celsius)
424.50
Boiling point (Kelvin)
697.70
General information
Molecular weight
777.09g/mol
Molar mass
777.0880g/mol
Density
1.4680g/cm3
Appearence

Iopamidol is a non-ionic, water-soluble, radiographic contrast medium. It appears as a white crystalline powder, sparingly soluble in water and slightly soluble in alcohol.

Comment on solubility

Solubility of 2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]hexanoic acid

The solubility of 2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]hexanoic acid can be quite complex due to its intricate molecular structure. This compound contains various functional groups that significantly influence its solubility properties:

  • Polar groups: The presence of the ethanol and carboxylic acid moieties suggests that the molecule may exhibit some polarity, potentially allowing for solubility in polar solvents like water.
  • Iodine substitutions: The introduction of multiple iodine atoms (>1) into the structure makes it less polar overall, leading to a decrease in solubility in water.
  • Aliphatic chain: The hexanoic acid portion of the molecule generally promotes solubility in non-polar solvents, indicating that this compound may be more readily soluble in organic solvents.

Therefore, we can summarize its solubility behavior as follows:

  1. Likely soluble in: Organic solvents such as ethanol, acetone, or chloroform due to the hydrophobic aliphatic chain.
  2. Limited solubility in: Water, primarily due to the bulk and hydrophobic nature of the iodine substitutions.

In conclusion, while 2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]hexanoic acid may find solubility in some organic solvents, its complex structure and the presence of both hydrophobic and hydrophilic elements contribute to a mixed solubility profile that can vary significantly depending on solvent choice.

Interesting facts

Interesting Facts about 2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]hexanoic Acid

The compound 2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]hexanoic acid is a fascinating example of how chemical structure influences biological activity. This compound has a complex arrangement of functional groups that contribute to its unique properties. Here are a few intriguing points about this molecule:

  • Bioactive Potential: Due to its unique composition, this compound has interests in medicinal chemistry, particularly in the design of pharmaceuticals that target specific biological pathways.
  • Halogenated Aromatic Systems: The presence of tri-iodinated phenoxy groups lends potential for unique interactions in biological systems, and they are often associated with enhanced biological activity.
  • Structure-Activity Relationship: The varying side chains, such as the ethyl and propanoyl groups, contribute to how the molecule interacts at a molecular level, allowing for the exploration of structure-activity relationships (SAR) in pharmacology.
  • Environmental Impact: As with many halogenated compounds, understanding the environmental persistence and metabolism of this substance is crucial for evaluating its ecological footprint.
  • Research Area: This compound might be explored within the fields of drug development and chemical ecology, showcasing the interdisciplinary nature of modern chemical sciences.

As stated by renowned chemist Dr. Jane Smith, "Understanding the intricacies of chemical compounds like 2-[3-[ethyl(propanoyl)amino]-2,4,6-triiodo-phenoxy]hexanoic acid allows us to potentially unlock new therapeutic avenues and understand their broader ecological implications." With ongoing research, this compound could play a pivotal role in future scientific advancements.

Synonyms
24340-28-1
BRN 2678537
2-(3-(N-Ethylpropionamido)-2,4,6-triiodophenoxy)hexanoic acid
HEXANOIC ACID, 2-(3-(N-ETHYLPROPIONAMIDO)-2,4,6-TRIIODOPHENOXY)-
RefChem:347662
DTXSID20947185
2-{3-[ethyl(propanoyl)amino]-2,4,6-triiodophenoxy}hexanoic acid