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Troglitazone

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Identification
Molecular formula
C4H3ClN2O2
CAS number
97322-87-7
IUPAC name
2-(3-methyl-2,4,5-trioxo-imidazolidin-1-yl)-N-(o-tolyl)propanamide
State
State

At room temperature, Troglitazone is found in a solid state. It is typically formulated as a powder, which may be compressed into tablets for pharmaceutical use.

Melting point (Celsius)
161.50
Melting point (Kelvin)
434.65
Boiling point (Celsius)
743.30
Boiling point (Kelvin)
1 016.45
General information
Molecular weight
441.53g/mol
Molar mass
441.5320g/mol
Density
1.2930g/cm3
Appearence

Troglitazone is a yellow to orange crystalline powder. It may also appear as a light tan crystalline solid depending on purity and manufacturing process. The compound is often observed in its powder form for pharmaceutical applications.

Comment on solubility

Solubility of 2-(3-methyl-2,4,5-trioxo-imidazolidin-1-yl)-N-(o-tolyl)propanamide

The solubility of 2-(3-methyl-2,4,5-trioxo-imidazolidin-1-yl)-N-(o-tolyl)propanamide is a topic of interest due to the unique nature of its molecular structure. Understanding its solubility can provide insights into its potential applications and behavior in various environments.

Factors influencing solubility:

  • Molecular structure: The presence of multiple functional groups, such as the imidazolidinyl and propanamide units, can affect the interaction with solvent molecules.
  • Polarity: The balance of polar and nonpolar regions in the compound influences its solubility in different solvents. Generally, polar compounds are better soluble in polar solvents.
  • Hydrogen bonding: The ability of the molecule to form hydrogen bonds can enhance solubility, especially in water.

Generally, this compound is expected to have moderate solubility due to the complex nature of its structure. Therefore, it would likely dissolve well in organic solvents while showing limited solubility in water. However, empirical data and experimental determination are essential for precise solubility values in specific solvents.

In summary, while the intricate structure of 2-(3-methyl-2,4,5-trioxo-imidazolidin-1-yl)-N-(o-tolyl)propanamide suggests moderate solubility characteristics, the exact solubility can depend on various factors and should be assessed through practical testing.

Interesting facts

Interesting Facts about 2-(3-methyl-2,4,5-trioxo-imidazolidin-1-yl)-N-(o-tolyl)propanamide

This intriguing compound, prominently featuring imidazolidin structures, captures the interest of chemists for several reasons:

  • Dual Functionality: The compound exhibits both amide and trioxo functionalities, which opens pathways for diverse chemical reactions. This duality makes it a valuable participant in synthetic organic chemistry.
  • Pharmaceutical Potential: Due to its structural characteristics, this compound may possess biologically active properties. Analyzing such compounds can lead to the discovery of novel drugs or therapeutic agents.
  • Synthetic Applications: Imidazolidin derivatives often serve as precursors or intermediates in the synthesis of other chemical entities, demonstrating their versatility in the laboratory.
  • Structure-Activity Relationship (SAR): The study of this compound's structure offers insights into how modifications can affect its activity, which is essential in medicinal chemistry for optimizing drug efficacy.

As we delve deeper into the analysis of such compounds, we realize that their complex structures often hold the key to unlocking new scientific knowledge. As one chemist famously said, "The beauty of chemistry lies in the endless possibilities and connections found within its compounds." In conclusion, 2-(3-methyl-2,4,5-trioxo-imidazolidin-1-yl)-N-(o-tolyl)propanamide is not just a formula, but a potential stepping stone in the world of chemical innovation.

Synonyms
1-Methyl-3-(1-(o-tolylcarbamoyl)ethyl)imidazolidinetrione
2211-52-1
BRN 0831549
DTXSID60944754
alpha,3-Dimethyl-2,4,5-trioxo-1-imidazolidineaceto-o-toluidide
1-Imidazolidineacetamide, alpha,3-dimethyl-N-(2-methylphenyl)-2,4,5-trioxo-
1-IMIDAZOLIDINEACETO-o-TOLUIDIDE, alpha,3-DIMETHYL-2,4,5-TRIOXO-
5-24-09-00056 (Beilstein Handbook Reference)
N-(2-Methylphenyl)-2-(3-methyl-2,4,5-trioxoimidazolidin-1-yl)propanimidic acid