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Clonidine

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Identification
Molecular formula
C9H9Cl2N5O2
CAS number
4205-90-7
IUPAC name
2-(3,11-dimethyl-6-oxo-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium;chloride
State
State

At room temperature, clonidine is typically in a solid state, appearing as a powder or crystalline substance. It is often used in pharmaceutical preparations and thus might be found in various oral dosage forms such as tablets.

Melting point (Celsius)
265.00
Melting point (Kelvin)
538.15
Boiling point (Celsius)
329.00
Boiling point (Kelvin)
602.15
General information
Molecular weight
266.12g/mol
Molar mass
266.1200g/mol
Density
1.3020g/cm3
Appearence

Clonidine appears as a crystalline substance. It is typically found in a solid state as a white or off-white powder. Being a pharmaceutical compound, its appearance can alter slightly depending on the formulation or form it is presented in, such as tablets.

Comment on solubility

Solubility of 2-(3,11-Dimethyl-6-oxo-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium Chloride

The solubility of 2-(3,11-dimethyl-6-oxo-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium chloride can be analyzed through several key factors.

Influencing Factors

  • Ionic Nature: As a quaternary ammonium salt, the presence of the chloride ion significantly influences its solubility in water.
  • Hydrogen Bonding: The structure may allow for hydrogen bonding with water molecules, enhancing its solubility.
  • Hydrophobicity: The large, hydrophobic benzo[b][1,4]benzodiazepin moiety may resist solubility in polar solvents but could be mitigated by the ionic ethyl-dimethyl-ammonium group.

General Solubility Behavior:

This compound is expected to be:

  • Soluble in Water: Its quaternary ammonium structure suggests it would dissolve well in aqueous solutions.
  • Limited Solubility in Organic Solvents: The hydrophobic nature of some of its components may limit its solubility in non-polar solvents.

In summary, the solubility profile of this compound is particularly influenced by its ionic moieties and bulky aromatic structures. As a general rule:

“Compounds with a balance of hydrophilic and hydrophobic characteristics tend to exhibit unique solubility behaviors in various solvents.”

Understanding the solubility can aid in the application and formulation of this compound in various chemical and pharmaceutical contexts.

Interesting facts

Interesting Facts about 2-(3,11-dimethyl-6-oxo-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium; chloride

This compound, an intriguing member of the benzodiazepine family, showcases a complex molecular structure that is worth exploring. Here are some captivating details:

  • Medication Potential: Compounds in the benzodiazepine class are known for their therapeutic uses, particularly in treating anxiety, insomnia, and other disorders. This particular compound's unique modifications may offer novel pharmacological properties.
  • Structure Importance: The presence of multiple methyl groups in its structure can significantly impact the compound's lipophilicity, potentially affecting how the molecule interacts with biological membranes and its overall pharmacokinetics.
  • Chloride Component: The inclusion of chloride as a counterion can be pivotal in determining the solubility and stability of the compound, leading to enhanced formulation possibilities in pharmaceutical applications.
  • Research Interest: As a scientist, one might find this compound intriguing for investigation in fields like medicinal chemistry, where the goal is to optimize the affinity and selectivity of drugs for their targets.
  • Tuning Activity: Modifications on the benzodiazepine core structure, like those seen in this compound, pave the way for adjusting its biological activity, making it an exciting area of study for drug design.

In conclusion, the study of 2-(3,11-dimethyl-6-oxo-benzo[b][1,4]benzodiazepin-5-yl)ethyl-dimethyl-ammonium; chloride not only enhances our understanding of drug behavior but also broadens the horizons for future therapeutic developments. As you explore this compound, think about its potential implications in both chemistry and medicine.

Synonyms
1162-96-5
5H-Dibenzo(b,e)(1,4)diazepin-11-one, 10,11-dihydro-5,8-dimethyl-10-(2-(dimethylamino)ethyl), hydrochloride