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Clonidine Hydrochloride

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Identification
Molecular formula
C9H10Cl2N2O•HCl
CAS number
4205-90-7
IUPAC name
2-[(3,4-dichlorophenoxy)methyl]-4,5-dihydro-1H-imidazole;hydrochloride
State
State

At room temperature, Clonidine hydrochloride is a solid.

Melting point (Celsius)
253.50
Melting point (Kelvin)
526.65
Boiling point (Celsius)
325.70
Boiling point (Kelvin)
598.85
General information
Molecular weight
266.15g/mol
Molar mass
266.1470g/mol
Density
1.4185g/cm3
Appearence

Clonidine hydrochloride appears as a white to almost white crystalline powder. It is hygroscopic, which means it can absorb moisture from the air, and is soluble in water and alcohol.

Comment on solubility

Solubility of 2-[(3,4-Dichlorophenoxy)methyl]-4,5-dihydro-1H-imidazole; hydrochloride

The solubility profile of 2-[(3,4-dichlorophenoxy)methyl]-4,5-dihydro-1H-imidazole; hydrochloride presents interesting characteristics that can be summarized as follows:

  • Hydrochloride Salt Formation: The hydrochloride form generally enhances water solubility compared to its free base, making it more bioavailable in aqueous solutions.
  • Polar Nature: The presence of the imidazole group, along with the chlorophenoxy moiety, introduces significant polar characteristics, which can contribute to enhanced solubility in polar solvents such as water.
  • Solvent Dependency: The solubility may vary significantly with changes in pH and the presence of other ions, as polar solutes often interact with solvent molecules.
  • Temperature Influence: Like many compounds, solubility can increase with rising temperature, resulting in altered dissolution rates.

In summary, the solubility of this compound is influenced by its chemical structure and environmental conditions. It highlights the complex interplay between molecular features and their interactions with solvents, making it a key consideration in formulations.

Interesting facts

Interesting Facts About 2-[(3,4-Dichlorophenoxy)methyl]-4,5-dihydro-1H-imidazole; Hydrochloride

This unique compound has garnered attention in the field of medicinal chemistry due to its intriguing structure and potential applications. Here are some noteworthy aspects:

  • Pharmaceutical Relevance: The compound is linked to the development of various pharmaceutical agents, particularly those targeting specific receptors in the body. Its imidazole core is often a structural motif found in numerous bioactive molecules.
  • Chlorophenoxy Group: The presence of the 3,4-dichlorophenoxy group is particularly interesting. This moiety is known for enhancing biological activity and can influence the compound's interaction with cellular targets. The chlorine substitutions often enhance the lipophilicity and metabolic stability of the molecule.
  • Structural Diversity: The compound exemplifies the fascinating diversity within organic synthesis. The combination of an imidazole ring with a dichlorophenyl moiety showcases how structural variations can lead to unique properties and potential functionalities.
  • Research Insights: Studies have suggested that compounds with similar structures may exhibit antifungal or antibacterial properties, making this a worthwhile avenue for ongoing research. Understanding how this compound interacts on a molecular level could lead to breakthroughs in drug design.
  • Protonation and Solubility: Being a hydrochloride salt, this compound features enhanced solubility in aqueous environments, making it easier to handle in laboratory settings and potentially increasing its bioavailability as a pharmaceutical substance.

In summary, 2-[(3,4-dichlorophenoxy)methyl]-4,5-dihydro-1H-imidazole; hydrochloride is not just a chemical entity; it is a gateway into the vast world of medicinal chemistry. As with many compounds, its full potential awaits exploration and discovery by curious minds in the scientific community. The future could hold exciting developments in its applications, making it a compound worthy of attention!

Synonyms
Fenmetozole hydrochloride
Fenmetozole HCl
23712-05-2
DH-524
Fenmetozole hydrochloride [USAN]
DH 524 (pharmaceutical)
UNII-AIW7IL0D0B
AIW7IL0D0B
2-((3,4-Dichlorophenoxy)methyl)-2-imidazoline hydrochloride
Fenmetozole hydrochloride (USAN)
2-((3,4-Dichlorophenoxy)methyl)-2-imidazoline monohydrochloride
DTXSID40178378
1H-Imidazole, 2-((3,4-dichlorophenoxy)methyl)-4,5-dihydro-, monohydrochloride
FENMETOZOLE HYDROCHLORIDE [MART.]
2-IMIDAZOLINE, 2-((3,4-DICHLOROPHENOXY)METHYL)-, MONOHYDROCHLORIDE
FENMETOZOLE HYDROCHLORIDE (MART.)
2-[(3,4-Dichlorophenoxy)methyl]-2-imidazoline monohydrochloride
RefChem:140163
DTXCID70100869
Fenmetazole
Fenmetozole (hydrochloride)
2-[(3,4-dichlorophenoxy)methyl]-4,5-dihydro-1H-imidazole hydrochloride
2-[(3,4-dichlorophenoxy)methyl]-4,5-dihydro-1H-imidazole;hydrochloride
SCHEMBL635494
orb1703451
CHEMBL2106194
SCHEMBL29913217
GLXC-06471
AKOS040745791
HY-105960A
DA-53153
CS-0086329
D04152
Q27273949