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Riluzole

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Identification
Molecular formula
C12H13Cl2F3N4
CAS number
1744-22-5
IUPAC name
2-[[(3,4-dichlorophenyl)-[4-(trifluoromethyl)phenyl]methylene]amino]guanidine
State
State

At room temperature, Riluzole is in a solid state. It appears as a powder, which is integral for its application in pharmaceutical preparations for oral administration.

Melting point (Celsius)
118.50
Melting point (Kelvin)
391.70
Boiling point (Celsius)
526.30
Boiling point (Kelvin)
799.50
General information
Molecular weight
234.16g/mol
Molar mass
234.1540g/mol
Density
1.5235g/cm3
Appearence

Riluzole is characterized as a white to slightly yellow powder. It is practically insoluble in water, only very slightly soluble in chloroform and ethanol, and soluble in methylene chloride.

Comment on solubility

Solubility of 2-[[(3,4-Dichlorophenyl)-[4-(Trifluoromethyl)phenyl]methylene]amino]guanidine

The solubility of 2-[[(3,4-dichlorophenyl)-[4-(trifluoromethyl)phenyl]methylene]amino]guanidine, a complex organic molecule, can be influenced by several factors, including its molecular structure and interactions with solvents. Here are some critical points to consider:

  • Polarity: The presence of dichlorophenyl and trifluoromethyl groups suggests the compound has certain polar characteristics, which may enhance solubility in polar solvents.
  • Hydrogen Bonding: As a guanidine derivative, it has the potential to form hydrogen bonds, impacting its solubility in various solvents, especially those capable of participating in hydrogen bonding.
  • Solvent Effects: Its solubility profile may vary greatly between different solvents. It is likely to be more soluble in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol compared to water.
  • Temperature Influence: Generally, an increase in temperature can lead to greater solubility for solids due to enhanced kinetic energy, allowing more molecular interactions with the solvent.

As a rule of thumb, *"like dissolves like,"* meaning a greater compatibility with solvents of similar polarity will enhance solubility. Understanding its solubility profile is crucial for effective applications in synthesis and formulation.

Interesting facts

Interesting Facts about 2-[[(3,4-Dichlorophenyl)-[4-(Trifluoromethyl)phenyl]methylene]amino]guanidine

This fascinating compound belongs to a class of chemicals known for their potential therapeutic applications. Here are some intriguing aspects to consider:

  • Antimicrobial Activity: Compounds with similar structures have shown promise as antimicrobial agents, providing a basis for research into new antibiotics amidst rising resistance issues.
  • Pharmaceutical Research: The unique functional groups present in this compound make it a subject of interest in drug development, particularly for diseases that involve complex pathways.
  • Environmental Chemistry: The presence of chlorine and fluorine within the structure indicates potential environmental implications. These halogens can affect the persistence and bioavailability of the compound in ecosystems.
  • Structure-Activity Relationship (SAR): The complex arrangement of functional groups supports investigations into SAR, helping scientists understand how modifications can influence biological activity.
  • Material Science: Due to its chemical stability, this compound may also be explored for use in materials science, potentially leading to innovative applications in coatings or polymers.

In conclusion, 2-[[(3,4-Dichlorophenyl)-[4-(Trifluoromethyl)phenyl]methylene]amino]guanidine not only showcases a unique and intricately designed molecular structure but also opens doors to extensive research possibilities across various scientific fields. The continual exploration of such compounds could lead to significant advancements in therapeutic strategies and materials technology.

Synonyms
SCHEMBL9853551
ADAFTDLZRBWZOK-UHFFFAOYSA-N
2-[[(3,4-dichlorophenyl)-[4-(trifluoromethyl)phenyl]methylidene]amino]guanidine