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Dopamine hydrochloride

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Identification
Molecular formula
C8H12ClNO2
CAS number
3414-22-2
IUPAC name
[2-(3,4-dihydroxyphenyl)-2-oxo-ethyl]-tetralin-2-yl-ammonium;chloride
State
State

At room temperature, dopamine hydrochloride exists as a solid. It is usually processed in its powder form for pharmaceutical use, often reconstituted with other substances to form solutions for medical treatments.

Melting point (Celsius)
243.00
Melting point (Kelvin)
516.15
Boiling point (Celsius)
270.00
Boiling point (Kelvin)
543.15
General information
Molecular weight
189.65g/mol
Molar mass
189.6490g/mol
Density
1.3800g/cm3
Appearence

Dopamine hydrochloride appears as a white to off-white crystalline powder. It is very hygroscopic, absorbing moisture from the air and may clump together if exposed to a humid environment. The solid is typically more stable when stored in a sealed container.

Comment on solubility

Solubility of [2-(3,4-dihydroxyphenyl)-2-oxo-ethyl]-tetralin-2-yl-ammonium;chloride

The solubility of the compound [2-(3,4-dihydroxyphenyl)-2-oxo-ethyl]-tetralin-2-yl-ammonium;chloride can be characterized by several key factors that influence its behavior in various solvents.

Factors Affecting Solubility

  • Ionic Nature: The presence of the chloride ion suggests a level of ionic solubility, making it more likely to dissolve in polar solvents.
  • Hydroxyl Groups: The two hydroxy groups enhance the potential for hydrogen bonding with water, further increasing solubility.
  • Molecular Structure: The bulky tetralin group may introduce steric hindrance, impacting the overall solubility in various solutions.

In practice, compounds of this nature typically exhibit improved solubility in:

  • Polar solvents (e.g., water, methanol)
  • Organic solvents with hydrogen-bonding capabilities (e.g., ethanol, dimethyl sulfoxide)

However, it is essential to note that although the chloride salt form is more soluble than the free base, the overall solubility may still be limited by the compound's molecular structure. As a rule of thumb, “Like dissolves like” is a good guiding principle; hence, solvent choice is critical in achieving effective dissolution.

Interesting facts

Interesting Facts about [2-(3,4-dihydroxyphenyl)-2-oxo-ethyl]-tetralin-2-yl-ammonium;chloride

This compound, while complex in its structure, provides fascinating insights into the world of organic chemistry and pharmacology. Its uniqueness can be attributed to several key features:

  • Structural Composition: This compound incorporates a tetralin moiety, which is a bicyclic aromatic compound, providing a stable backbone that is crucial for its reactivity and interaction with biological systems.
  • Phenolic Functionality: The presence of the 3,4-dihydroxyphenyl group introduces hydroxyl functional groups that can enhance the compound's solubility and reactivity, allowing it to participate in various biochemical pathways.
  • Potential Biological Activity: Compounds with similar structures are often investigated for their potential as pharmaceuticals. They might exhibit antioxidant, anti-inflammatory, or other therapeutic properties that could be beneficial in medicinal chemistry.
  • Ionic Properties: As a chloride salt, this compound's ionic characteristics can influence its biological availability and distribution in the body, making it a significant consideration for drug development.

In scientific literature, compounds like this one are pivotal in developing new drugs. As chemists often say, "The structure of the molecule determines its function." Therefore, understanding the nuances of such compounds can lead to groundbreaking discoveries in pharmacology and material science.

Overall, [2-(3,4-dihydroxyphenyl)-2-oxo-ethyl]-tetralin-2-yl-ammonium;chloride stands as a testament to the intricate design of chemical compounds that bridge the gap between chemistry and biology, showcasing the endless possibilities within the realm of medicinal research.

Synonyms
N-beta-Tetra-hydronaphthyl noradrenalone hydrochloride
3',4'-Dihydroxy-2-((1,2,3,4-tetrahydro-2-naphthyl)amino)acetophenone hydrochloride
N-beta-Tetrahydronaphthylnoradrenalone hydrochloride
Acetophenone, 3',4'-dihydroxy-2-((1,2,3,4-tetrahydro-2-naphthyl)amino)-, hydrochloride
16149-22-7