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Guazatine

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Identification
Molecular formula
C10H15N3O2
CAS number
13516-27-3
IUPAC name
2-[(3,4-dimethoxyphenyl)methyl]guanidine
State
State
Guazatine is typically a solid at room temperature, appearing as a crystalline compound. However, it can be processed into a liquid form when dissolved in appropriate solvents for its applications.
Melting point (Celsius)
130.00
Melting point (Kelvin)
403.15
Boiling point (Celsius)
365.00
Boiling point (Kelvin)
638.15
General information
Molecular weight
239.29g/mol
Molar mass
239.2850g/mol
Density
1.1300g/cm3
Appearence

Guazatine, or 2-[(3,4-dimethoxyphenyl)methyl]guanidine, typically appears as a colorless to pale yellow crystalline solid. It is often used in various formulations and may appear as a solution if dissolved for practical applications.

Comment on solubility

Solubility of 2-[(3,4-Dimethoxyphenyl)methyl]guanidine

The solubility of 2-[(3,4-dimethoxyphenyl)methyl]guanidine in various solvents is influenced by its molecular structure, particularly the presence of the dimethoxyphenyl group. Understanding its solubility is essential for applications in pharmaceuticals and chemical synthesis. Here are key points regarding its solubility:

  • Polar Protic Solvents: This compound is expected to show good solubility in polar protic solvents such as water and alcohols due to the presence of guanidine functional groups, which can form hydrogen bonds.
  • Non-Polar Solvents: Its solubility in non-polar solvents may be lower, as the hydrophobic character of the dimethoxyphenyl group can hinder interaction with non-polar molecules.
  • pH Sensitivity: The solubility can also be pH-dependent. In acidic or basic environments, protonation or deprotonation of the guanidine group could significantly alter its solubility profile.
  • Overall Solubility: It is expected to show variable solubility, likely dissolving better in organic solvents that can solvate both the polar guanidine and the aromatic moiety.

As stated, “solubility plays a pivotal role in determining the bioavailability and efficacy of pharmaceutical compounds.” Understanding the solubility characteristics of 2-[(3,4-dimethoxyphenyl)methyl]guanidine will guide researchers in optimizing formulations for therapeutic use.

Interesting facts

Interesting Facts about 2-[(3,4-Dimethoxyphenyl)methyl]guanidine

2-[(3,4-dimethoxyphenyl)methyl]guanidine, often abbreviated as DMG, is a fascinating compound that showcases the intersection of organic chemistry and pharmacology. This compound is particularly noteworthy for several reasons:

  • Pharmacological Potential: DMG is investigated for its possible therapeutic properties. It has been noted in research for its ability to act as a modulator in various biological systems, suggesting potential applications in medical treatments.
  • Chemical Structure: The structure of DMG features a guanidine group, which plays a significant role in its reactivity and interaction with biological targets. Its unique arrangement of methoxy groups on the aromatic ring enhances its lipid solubility, helping it to permeate cell membranes effectively.
  • Synthesis: The synthesis of DMG involves notable organic reactions. Chemists often utilize methods such as alkylation and condensation reactions to derive the compound efficiently, making it a valuable asset in synthetic organic chemistry.
  • Potential as a Research Tool: Its interesting properties make it a compound of choice in various studies, particularly in neuropharmacology and drug design, where guanidine derivatives have shown promising results.
  • Structure-Activity Relationship (SAR): Researchers study DMG to understand how modifications to its structure can alter its biological activity, providing insights into designing new compounds with desired effects.

As with many chemical entities, the study of 2-[(3,4-dimethoxyphenyl)methyl]guanidine opens up numerous avenues for research and potential applications that can enhance our understanding of medicinal chemistry.
Its blend of interesting structural features and promising pharmacological effects makes it a noteworthy compound in the field!

Synonyms
1-(3,4-Dimethoxybenzyl)guanidine
19889-43-1
2-[(3,4-dimethoxyphenyl)methyl]guanidine
N-(3,4-dimethoxybenzyl)guanidine
veratrylguanidine
N-[(3,4-dimethoxyphenyl)methyl]guanidine
CHEMBL460938
SCHEMBL1186351
SCHEMBL5243976
DTXSID80274883
WQPOSQDIXGOFCT-UHFFFAOYSA-N
MFCD16662847
STL185733
AKOS009145561
BS-4187
SY340537
CS-0336580