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Proguanil

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Identification
Molecular formula
C11H16N5O2
CAS number
500-92-5
IUPAC name
2-[(3,4-dipropoxyphenyl)methyl]guanidine
State
State

At room temperature, Proguanil is in a solid state, specifically as a crystalline powder.

Melting point (Celsius)
221.00
Melting point (Kelvin)
494.15
Boiling point (Celsius)
337.10
Boiling point (Kelvin)
610.25
General information
Molecular weight
253.28g/mol
Molar mass
253.3350g/mol
Density
1.1516g/cm3
Appearence

Proguanil typically appears as a white or almost white crystalline powder. It is sparingly soluble in water and soluble in alcohol and chloroform. Under standard conditions, it presents a fine, powdery appearance.

Comment on solubility

Solubility of 2-[(3,4-dipropoxyphenyl)methyl]guanidine

The solubility of 2-[(3,4-dipropoxyphenyl)methyl]guanidine in various solvents can be influenced by its molecular structure and interactions with different environments. Here are some key points to consider:

  • Polar vs. Non-Polar Solvents: Due to the presence of guanidine functional groups, which are polar in nature, this compound is likely to exhibit higher solubility in polar solvents, such as water or alcohols. Conversely, its non-polar dipropoxyphenyl moiety may lead to lower solubility in non-polar solvents.
  • Hydrogen Bonding: The guanidine group can participate in hydrogen bonding, potentially enhancing solubility in solvents capable of forming hydrogen bonds.
  • Chain Length Effects: The presence of the dipropoxy side chains might affect the overall solubility by introducing hydrophobic interactions, thus making it less soluble in water but possibly more soluble in organic solvents.
  • Temperature Dependence: The solubility may vary significantly with temperature; generally, higher temperatures increase solubility for many compounds.

In summary, the solubility of 2-[(3,4-dipropoxyphenyl)methyl]guanidine is a complex interplay of its structural characteristics and the nature of the solvent. As with many organic substances, understanding its solubility is essential for applications in pharmaceuticals, material science, and chemical synthesis.

Interesting facts

Interesting Facts about 2-[(3,4-dipropoxyphenyl)methyl]guanidine

2-[(3,4-dipropoxyphenyl)methyl]guanidine is a fascinating compound that belongs to the family of guanidines, which are known for their diverse applications and biological significance. Here are some noteworthy points about this compound:

  • Pharmacological Potential: This compound has garnered attention in pharmaceutical research due to its potential role in antidiabetic therapies. It represents a key structure that could help in the modulation of glucose metabolism.
  • Structure and Function: The unique structure featuring a dipropoxyphenyl moiety enhances its ability to interact with various biological targets. This can result in improved pharmacokinetic properties compared to simpler guanidine derivatives.
  • Research Applications: Studies have explored its application in medicinal chemistry as a scaffold for designing novel therapeutic agents that require specific molecular interactions.
  • Versatile Synthesis: The synthesis of this compound can be achieved through various organic reactions, showcasing the compound's accessibility for researchers involved in synthetic chemistry.
  • Biological Pathways: Investigations have indicated the potential involvement of such guanidine derivatives in important biological pathways, which could lead to breakthroughs in understanding disease mechanisms.

Overall, 2-[(3,4-dipropoxyphenyl)methyl]guanidine is more than just a chemical compound; it is a promising candidate that bridges the gap between chemical structure and biological function. As research continues, it may offer valuable insights into the development of new medications and therapies.