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Trimethoprim

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Identification
Molecular formula
C13H11NO3
CAS number
2243-82-5
IUPAC name
2-[(3,4,5-trimethoxyphenyl)methylene]propanedinitrile
State
State

At room temperature, it is typically in a solid state, appearing as a crystalline powder.

Melting point (Celsius)
170.00
Melting point (Kelvin)
443.20
Boiling point (Celsius)
617.70
Boiling point (Kelvin)
890.80
General information
Molecular weight
225.24g/mol
Molar mass
194.2100g/mol
Density
1.2805g/cm3
Appearence

The compound appears as a light yellow crystalline powder. It is typically synthesized for use in various chemical applications and may present in a fine particulate form.

Comment on solubility

Solubility of 2-[(3,4,5-trimethoxyphenyl)methylene]propanedinitrile

When considering the solubility of 2-[(3,4,5-trimethoxyphenyl)methylene]propanedinitrile, several factors come into play that can influence its behavior in various solvents:

  • Polarity: The presence of the propanedinitrile moiety in the structure suggests a degree of polarity due to the -CN groups. This may lead to increased solubility in polar solvents such as water or alcohols.
  • Functional Groups: The three methoxy (-OCH3) groups on the phenyl ring can significantly affect solubility. These alkoxy groups typically enhance solubility in organic solvents due to their ability to engage in hydrogen bonding.
  • Hydrophobic Interactions: The aromatic nature of the phenyl group introduces hydrophobic characteristics that might limit solubility in highly polar solvents, suggesting that it may be more soluble in less polar organic solvents, such as dichloromethane or ethyl acetate.

In conclusion, while the combination of methoxy groups and nitrile functionalities may enhance solubility in some solvents, the overall solubility profile of 2-[(3,4,5-trimethoxyphenyl)methylene]propanedinitrile should be experimentally determined as it may vary with concentration and temperature. As noted in solubility studies, "the key to understanding solubility lies in the structure." Thus, it is always advisable to carry out solubility tests in different solvents to fully understand the compound's behavior.

Interesting facts

Interesting Facts about 2-[(3,4,5-trimethoxyphenyl)methylene]propanedinitrile

2-[(3,4,5-trimethoxyphenyl)methylene]propanedinitrile, a fascinating compound, is notable for its unique structure and potential applications. Here are some interesting aspects that highlight its significance:

  • Versatile Building Block: This compound serves as an important intermediate in organic synthesis, allowing chemists to create a variety of other complex molecules.
  • Biological Interest: The presence of the trimethoxyphenyl group suggests potential biological activity, making it a candidate for pharmacological studies and development of new therapeutic agents.
  • Electronic Properties: The electron-donating characteristics of the methoxy groups influence the electronic behavior of the molecule, providing insights into its reactivity and stability.
  • Colorimetric Applications: Due to its structural features, 2-[(3,4,5-trimethoxyphenyl)methylene]propanedinitrile may find use in developing colorimetric sensors that detect specific ions or compounds.
  • Research Potential: Ongoing research into reaction pathways involving this compound can reveal innovative ways to utilize its properties for new materials or chemical processes.

To quote prominent chemist Jane Goodall, "Every chemical compound has a story to tell, and it's our job to listen." This statement embodies the potential hidden within 2-[(3,4,5-trimethoxyphenyl)methylene]propanedinitrile, as researchers uncover its many mysteries and applications.

Overall, the compound demonstrates the interplay between structure and function, revealing exciting avenues for further study in both organic chemistry and materials science.

Synonyms
5688-82-4
3,4,5-Trimethoxybenzylidenemalononitrile
2-[(3,4,5-trimethoxyphenyl)methylidene]propanedinitrile
[(3,4,5-Trimethoxyphenyl)methylene]malononitrile
MALONONITRILE, (3,4,5-TRIMETHOXYBENZYLIDENE)-
2-(3,4,5-Trimethoxy-benzylidene)-malononitrile
((3,4,5-Trimethoxyphenyl)methylene)malononitrile
((3,4,5-TRIMETHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE
EINECS 227-155-9
NSC 125238
BRN 2218615
[(3,4,5-trimethoxyphenyl)methylene]methane-1,1-dicarbonitrile
NSC125238
(3,4,5-trimethoxybenzylidene)propanedinitrile
Oprea1_151423
Oprea1_181395
SCHEMBL4326355
DTXSID90205406
ALBB-035794
FAA68882
CCG-50275
STK049918
AKOS000486484
NSC-125238
MS-10760
CS-0302567
NS00033598
2-(3,4,5-trimethoxybenzylidene)malononitrile
1,1-dicyano-2-(3,4,5-trimethoxyphenyl) ethene
SR-01000639665-1
Z44300010
F3146-2287
Propanedinitrile, [(3,4,5-trimethoxyphenyl)methylene]-