Skip to main content

piperonylpiperazine derivative

ADVERTISEMENT
Identification
Molecular formula
C20H21FN2O3
CAS number
82801-83-2
IUPAC name
2-[4-(1,3-benzodioxol-2-ylmethyl)piperazin-1-yl]-1-(4-fluorophenyl)ethanone
State
State

At room temperature, this compound is in a solid state.

Melting point (Celsius)
193.00
Melting point (Kelvin)
466.15
Boiling point (Celsius)
409.20
Boiling point (Kelvin)
682.35
General information
Molecular weight
342.37g/mol
Molar mass
342.3680g/mol
Density
1.2470g/cm3
Appearence

The compound typically forms as a crystalline solid. It may appear in white to off-white crystalline powder form, depending on its purity and conditions of synthesis.

Comment on solubility

Solubility of 2-[4-(1,3-benzodioxol-2-ylmethyl)piperazin-1-yl]-1-(4-fluorophenyl)ethanone

The solubility of 2-[4-(1,3-benzodioxol-2-ylmethyl)piperazin-1-yl]-1-(4-fluorophenyl)ethanone is influenced by several factors including its chemical structure and polarity. Understanding the solubility characteristics of this compound is vital for its applications in various fields.

Key Points on Solubility:

  • Polarity: The presence of polar functional groups, such as the ethyl ketone and piperazine, increases the compound's ability to dissolve in polar solvents like water and alcohol.
  • Hydrophobic regions: The benzodioxole and benzene rings contribute to hydrophobic characteristics, which can enhance solubility in organic solvents.
  • Temperature Effects: Generally, an increase in temperature can improve the solubility of solids, and thus, it may be beneficial to test solubility at elevated temperatures.
  • pH Dependency: The ionization state of the piperazine group may vary with pH, affecting the overall solubility in aqueous solutions.

To summarize, the solubility of 2-[4-(1,3-benzodioxol-2-ylmethyl)piperazin-1-yl]-1-(4-fluorophenyl)ethanone can be considered moderate to high in suitable polar solvents, whereas its solubility in nonpolar solvents should be assessed individually. This makes it a versatile compound for use in various chemical environments.

Interesting facts

Overview of 2-[4-(1,3-benzodioxol-2-ylmethyl)piperazin-1-yl]-1-(4-fluorophenyl)ethanone

This compound is a fascinating example of a synthetic molecule that merges various organic structures to create a unique and potentially bioactive compound. It showcases intricate connections that highlight the creativity and precision often employed in the field of organic chemistry.

Key Features

  • Piperazine ring: This compound contains a piperazine moiety, which is a common core structure in pharmaceutical chemistry known for its effects on neurotransmitter systems.
  • Benzodioxole group: The presence of the benzodioxole structure adds interesting properties and can influence the compound’s interaction with biological targets, making it relevant in medicinal chemistry.
  • Fluorine substitution: The 4-fluorophenyl group is particularly noteworthy, as fluorine atoms can greatly enhance the metabolic stability and bioavailability of chemical entities.

Applications and Research

This compound’s elaborate structure positions it well for various applications, particularly in drug development and therapeutic research. Some exciting areas of interest include:

  • Neuropharmacology: Due to its piperazine core, it may exhibit activity as an anxiolytic or antidepressant.
  • Synthetic pathways: Understanding how to synthesize such complex molecules can lead to advancements in synthetic chemistry methodologies.
  • Structure-activity relationships (SAR): Investigating how modifications to this compound affect its biological activity is a staple in drug design.

Final Thoughts

As we delve deeper into the capabilities of compounds like 2-[4-(1,3-benzodioxol-2-ylmethyl)piperazin-1-yl]-1-(4-fluorophenyl)ethanone, we continue to unlock new potentials for therapeutic applications. Understanding the subtle nuances of its chemical structure and how they relate to its biological properties emphasizes the importance of interdisciplinary research in chemistry and biology.

In the words of renowned chemist Linus Pauling, "There is no such thing as a secret in science." The exploration of compounds like this one reveals the beauty behind the intricate network of chemical interactions that drive life and innovation.

Synonyms
BRN 0899380
1-(4-Fluorophenacyl)-4-piperonylpiperazine
2194-75-4
4'-Fluoro-2-(4-piperonyl-piperazin-1-yl)acetophenone
ACETOPHENONE, 4'-FLUORO-2-(4-PIPERONYLPIPERAZIN-1-YL)-
5-23-02-00529 (Beilstein Handbook Reference)
DTXSID00944536
2-{4-[(2H-1,3-Benzodioxol-2-yl)methyl]piperazin-1-yl}-1-(4-fluorophenyl)ethan-1-one