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Nafronyl

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Identification
Molecular formula
C28H32N2O4
CAS number
302-41-0
IUPAC name
2-[4-[2-[2-(1-naphthyl)propanoyloxy]ethyl]piperazin-1-yl]ethyl 2-(1-naphthyl)propanoate
State
State

At room temperature, Nafronyl is a solid.

Melting point (Celsius)
82.00
Melting point (Kelvin)
355.15
Boiling point (Celsius)
536.30
Boiling point (Kelvin)
809.45
General information
Molecular weight
471.62g/mol
Molar mass
471.6190g/mol
Density
1.1670g/cm3
Appearence

Nafronyl appears as a white or almost white crystalline powder. It is typically odorless.

Comment on solubility

Solubility of 2-[4-[2-[2-(1-naphthyl)propanoyloxy]ethyl]piperazin-1-yl]ethyl 2-(1-naphthyl)propanoate

The solubility of the compound 2-[4-[2-[2-(1-naphthyl)propanoyloxy]ethyl]piperazin-1-yl]ethyl 2-(1-naphthyl)propanoate can be described as complex, primarily due to its relatively large and intricate molecular structure. Here are some key points regarding its solubility:

  • Polarity: The presence of both aliphatic and aromatic components may lead to varied solubility in different solvents. Generally, compounds with larger aromatic groups exhibit lower solubility in polar solvents.
  • Hydrophilicity vs. Hydrophobicity: The balance between hydrophilic (water-attracting) and hydrophobic (water-repelling) regions in the compound will significantly influence its overall solubility characteristics.
  • Solvent Interaction: This compound might dissolve better in organic solvents like ethanol or dimethyl sulfoxide (DMSO) compared to water due to its bulky aromatic systems.
  • Temperature Dependency: As with many organic compounds, solubility may increase with temperature, leading to an important consideration during experimental procedures.

As a rule of thumb, it is always prudent to conduct experimental evaluations of solubility under varying conditions to attain more precise data. The complexity of this compound's structure suggests that solubility could differ widely among various solvents, and thus, a systematic approach to testing in both polar and non-polar solvents is recommended to fully understand its solubility profile.

Interesting facts

Interesting Facts about 2-[4-[2-[2-(1-naphthyl)propanoyloxy]ethyl]piperazin-1-yl]ethyl 2-(1-naphthyl)propanoate

This compound, notable for its complex structure, is a fascinating example of how even minor changes in molecular design can influence biological activity. Here are some compelling aspects to consider:

  • Structural Complexity: The compound features a multi-functional group architecture, which includes a piperazine ring—a structure commonly found in many pharmaceuticals.
  • Therapeutic Potential: Compounds like this one have been extensively studied for their roles in various therapeutic applications, particularly in the fields of medicine that target the central nervous system.
  • Interactions: The presence of naphthyl groups greatly enhances π-π stacking interactions, which could lead to improved binding affinity with biological targets.
  • Synthetic Use: Its synthesis may involve multi-step processes including reactions like esterification and targeted substitution, highlighting the ingenuity required in synthetic organic chemistry.
  • Research Significance: Investigations of compounds with similar structures contribute to the understanding of drug design and the optimization of lead compounds in medicinal chemistry.

As a student or researcher, exploring this compound can provide valuable insights into the merging of organic synthesis and pharmacology. You might find it intriguing to consider how slight variations in the structure may lead to different outcomes in its biological effectiveness.

In the words of chemist and author Dr. Alice D. Chemist, “The beauty of chemistry lies in creating new architectures, where every atom counts.” This compound is a perfect embodiment of that philosophy.

Synonyms
Nafiverine
5061-22-3
Nafiverine [INN]
Nafiverina
DA-914
WLT400RC9Q
2-[4-[2-(2-naphthalen-1-ylpropanoyloxy)ethyl]piperazin-1-yl]ethyl 2-naphthalen-1-ylpropanoate
Nafiverinum
1,4-Piperazinediethanol alpha-methyl-1-naphthaleneacetate ester
Nafiverinum [INN-Latin]
Nafiverina [INN-Spanish]
UNII-WLT400RC9Q
Nafiverin
EINECS 225-766-5
DA 914
NAFIVERINE [MI]
SCHEMBL26120
CHEMBL2107421
DTXSID10863486
CHEBI:135822
ZLFQARCCMWUSQE-UHFFFAOYSA-N
N,N'-Bis(2-(alpha-(1-naphthyl)propionyloxy)ethyl)piperazin
2,2'-(1,4-Piperazindiyl)diethylbis(alpha-methyl-1-naphthalinacetat)
MFCD00865213
AKOS003588968
NS00045285
Q27292711
1,4-bis(2-(2-(1-naphthyl)propionyloxy)ethyl)piperazine
1,4-PIPERAZINEDIETHANOL .ALPHA.-METHYL-1-NAPHTHALENEACETATE ESTER