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Naproxen dihydrochloride

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Identification
Molecular formula
C14H14Cl2N2O4
CAS number
26159-34-2
IUPAC name
2-[4-[2-[2-(1-naphthyl)propanoyloxy]ethyl]piperazin-1-yl]ethyl 2-(1-naphthyl)propanoate;dihydrochloride
State
State

At room temperature, naproxen dihydrochloride is typically in a solid state, appearing as a crystalline powder. It is usually handled as a solid powder, and its physical form is suitable for its incorporation into various dosage forms in the pharmaceutical industry.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.15
Boiling point (Celsius)
409.70
Boiling point (Kelvin)
682.85
General information
Molecular weight
270.35g/mol
Molar mass
270.3480g/mol
Density
1.4400g/cm3
Appearence

Naproxen dihydrochloride typically appears as a white or off-white crystalline powder. This compound, as a salt form of naproxen, might exhibit better water solubility compared to its free acid form, which is beneficial for its formulation in pharmaceutical applications.

Comment on solubility

Solubility of 2-[4-[2-[2-(1-naphthyl)propanoyloxy]ethyl]piperazin-1-yl]ethyl 2-(1-naphthyl)propanoate; dihydrochloride

The solubility characteristics of the compound 2-[4-[2-[2-(1-naphthyl)propanoyloxy]ethyl]piperazin-1-yl]ethyl 2-(1-naphthyl)propanoate; dihydrochloride are intriguing and can be described as follows:

  • Solubility in Water: This compound's dihydrochloride form is likely soluble in water due to the presence of two hydrochloride groups, which can enhance ionic interactions with water molecules.
  • Organic Solvents: It may show varying solubility in organic solvents, depending on the specific interactions with their molecular structures.
  • pH Dependence: Its solubility might be influenced by the pH of the solution, with potential differences observed between acidic and neutral conditions.
  • Form of Administration: The solubility profile is crucial for pharmaceutical applications, affecting absorption and bioavailability.

In conclusion, the solubility of 2-[4-[2-[2-(1-naphthyl)propanoyloxy]ethyl]piperazin-1-yl]ethyl 2-(1-naphthyl)propanoate; dihydrochloride is a key factor influencing its applications in both research and medicinal chemistry. Understanding its solubility can lead to better formulation strategies and enhanced therapeutic efficacy.

Interesting facts

Interesting Facts about 2-[4-[2-[2-(1-naphthyl)propanoyloxy]ethyl]piperazin-1-yl]ethyl 2-(1-naphthyl)propanoate; dihydrochloride

This intriguing compound, with a complex structure, showcases the fascinating world of organic chemistry. Here are some notable aspects:

  • Pharmaceutical Relevance: This molecule falls within the category of pharmaceutical compounds, indicating its potential use in medicinal applications, possibly as a drug or therapeutic agent.
  • Ring Structures: The inclusion of piperazine in its structure suggests interesting pharmacological properties, as piperazine derivatives are known for their diverse biological activities.
  • Naphthyl Groups: The presence of naphthyl groups signifies enhanced hydrophobic interactions, which can influence the binding affinity of the compound to biological targets. Naphthyl moieties are often associated with increased potency in drug design.
  • Polyfunctionality: This compound possesses multiple functional groups that can participate in various chemical reactions, making it a versatile building block in synthetic organic chemistry.
  • Complex Formation: The dihydrochloride form of this compound may suggest improved solubility or stability under physiological conditions, enhancing its bioavailability and effectiveness in biological systems.

In summary, the compound exemplifies the rich interplay between structure and function in medicinal chemistry. Its multifaceted properties open avenues for research and development in drug discovery. As a student or an enthusiast in chemistry, unlocking the potential of such compounds is both a challenge and a rewarding endeavor.

Synonyms
5051-16-1
N,N'-Di(alpha-(1-naphthyl)propionyloxy-2-ethyl)piperazine dihydrochloride
Naftimepezine
Nafiverine dihydrochloride
Nafiverine HCl
N,N'-Bis(2-(alpha-(1-naphthyl)propionyloxy)ethyl)piperazin hydrochlorid
1,4-Piperazinediethanol alpha-methyl-1-naphthaleneacetate ester dihydrochloride
2,2'-(1,4-Piperazindiyl)diethylbis(alpha-methyl-1-naphtalinacetat) dihydrochloride
DTXSID80964737
1-Naphthaleneacetic acid, alpha-methyl-, 1,4-piperazinediyldi-2,1-ethanediyl ester, dihydrochloride
(Piperazine-1,4-diyl)di(ethane-2,1-diyl) bis[2-(naphthalen-1-yl)propanoate]--hydrogen chloride (1/2)
2-[4-[2-(2-naphthalen-1-ylpropanoyloxy)ethyl]piperazin-1-yl]ethyl 2-naphthalen-1-ylpropanoate;dihydrochloride