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Cidofovir

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Identification
Molecular formula
C8H14N3O5P
CAS number
113852-37-2
IUPAC name
2-[[4-[2-[2-[3-acetamido-2-[[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxypropanoylamino]propanoylamino]-4-carboxy-butanoyl]amino]-6-amino-heptanedioic acid
State
State

At room temperature, Cidofovir is typically a solid.

Melting point (Celsius)
260.00
Melting point (Kelvin)
533.20
Boiling point (Celsius)
567.30
Boiling point (Kelvin)
840.50
General information
Molecular weight
315.20g/mol
Molar mass
315.2200g/mol
Density
2.1000g/cm3
Appearence

Cidofovir generally appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-[[4-[2-[2-[3-acetamido-2-[[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxypropanoylamino]propanoylamino]-4-carboxy-butanoyl]amino]-6-amino-heptanedioic acid

The solubility of complex compounds such as 2-[[4-[2-[2-[3-acetamido-2-[[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxypropanoylamino]propanoylamino]-4-carboxy-butanoyl]amino]-6-amino-heptanedioic acid (C8H14N3O5P) can be influenced by several factors. Here are some key points to consider:

  • Polar and Nonpolar Interactions: With multiple functional groups like amino, carboxylic acid, and hydroxyl, the compound is likely polar, which enhances solubility in polar solvents such as water.
  • Hydrogen Bonding: The presence of hydroxyl and amino groups can form hydrogen bonds with solvent molecules, substantially increasing solubility.
  • pH Dependence: The solubility may vary with the pH of the solution, especially due to carboxylic acid groups becoming more ionized at higher pH levels.
  • Molecular Size: Larger, complex molecules often exhibit lower solubility compared to smaller compounds due to steric hindrance that can impede interaction with solvent molecules.
  • Structural Integrity: The intricate structure containing multiple rings and functional groups may affect stability, influencing solubility in various solvents.

Overall, while this compound is anticipated to be soluble in polar solvents, the exact solubility may require empirical testing to elucidate its behavior in various environments. As in the words of chemist Linus Pauling, "The best way to get a good idea is to have lots of ideas," and this rings true as one explores solubility characteristics through experimentation and observation.

Interesting facts

Interesting Facts about 2-[[4-[2-[2-[3-acetamido-2-[[[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-5-hydroxy-6-(hydroxymethyl)tetrahydropyran-4-yl]oxypropanoylamino]propanoylamino]-4-carboxy-butanoyl]amino]-6-amino-heptanedioic acid

This compound, due to its intricate structure and multiple functional groups, presents a fascinating area of study in biochemistry and pharmaceutical research. Here are some noteworthy facts:

  • Complex Structure: This compound exhibits a highly complex and branched structure. The presence of multiple amino, carboxylic, and phosphoryl groups suggests potential roles in biochemical pathways.
  • Medicinal Applications: Given its structural motifs, it could serve as a candidate for drug development, particularly in targeting metabolic disorders or as a nucleotide analog.
  • Pharmacophore Features: The incorporation of a dioxopyrimidine moiety could enhance molecular interactions with biological targets, potentially leading to increased activity in therapeutic applications.
  • Research Opportunities: This compound provides ample opportunity for research into enzyme inhibition, possibly acting on pathways related to nucleic acid metabolism or signaling.

In sum, the compound's intricate composition, combined with its potential applicability in therapeutic development, positions it as an intriguing subject of study in both academic and pharmaceutical settings. As one researcher aptly put it, "The more complex the structure, the more fascinating the potential!"

Synonyms
SCHEMBL26037262