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Methotrexate

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Identification
Molecular formula
C20H22N8O5
CAS number
59-05-2
IUPAC name
2-[[4-[2-(2-amino-4-oxo-1H-quinazolin-6-yl)-1-carboxy-ethyl]benzoyl]amino]pentanedioic acid
State
State

At room temperature, methotrexate is in a solid state. It is generally available in powder form for medicinal purposes.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
364.50
Boiling point (Kelvin)
637.65
General information
Molecular weight
454.44g/mol
Molar mass
454.4420g/mol
Density
1.2300g/cm3
Appearence

Methotrexate is a yellow to orange crystalline powder. It is usually odorless and light-sensitive.

Comment on solubility

Solubility of 2-[[4-[2-(2-amino-4-oxo-1H-quinazolin-6-yl)-1-carboxy-ethyl]benzoyl]amino]pentanedioic acid

The solubility of 2-[[4-[2-(2-amino-4-oxo-1H-quinazolin-6-yl)-1-carboxy-ethyl]benzoyl]amino]pentanedioic acid (C20H22N8O5) can be influenced by various factors such as pH, temperature, and the presence of other solutes. Here are some important considerations:

  • Polarity: Due to the presence of polar functional groups, such as carboxylic acids and amines, this compound may exhibit moderate solubility in polar solvents like water.
  • pH Sensitivity: The solubility can significantly change with variations in pH levels. For example, it may be more soluble in acidic conditions where carboxylic acids are protonated.
  • Temperature Dependence: Like many organic compounds, increased temperature may enhance solubility, potentially aiding in dissolution rates.
  • Comparative Solubility: When compared to other similar compounds, this particular chemical may show varying degrees of solubility, making its behavior in solvents unique.

In summary, the solubility of this complex molecule is determined by a combination of its molecular structure and external environmental factors. Understanding these dynamics is essential for effective use in applications such as pharmaceuticals and chemical research.

Interesting facts

Interesting Facts about 2-[[4-[2-(2-amino-4-oxo-1H-quinazolin-6-yl)-1-carboxy-ethyl]benzoyl]amino]pentanedioic acid

This intriguing compound is a member of the quinazoline family, which is notable for its wide range of biological activities. Quinazoline derivatives have been extensively studied for their potential roles in medicinal chemistry, particularly in the development of pharmaceuticals.

Key Features:

  • Biological Relevance: Compounds with quinazoline structures are often investigated for their anti-cancer, anti-bacterial, and anti-inflammatory properties. This highlights their significance in drug design and discovery.
  • Structural Complexity: As a derivative featuring both amino and carboxylic acid functional groups, this compound exemplifies intricate chemical architecture, which contributes to its diverse reactivity profiles.
  • Targeted Therapy: The arrangement of functional groups may enable this compound to selectively target cellular receptors or enzymes, making it a candidate for exploring pathways in targeted therapy treatments.

In the realm of organic chemistry, this compound serves not only as a fascinating example of structure-activity relationships but also as an essential actor in potential therapeutic applications. Researchers are continually excited by the discoveries surrounding quinazoline derivatives, and as such, the exploration into compounds like 2-[[4-[2-(2-amino-4-oxo-1H-quinazolin-6-yl)-1-carboxy-ethyl]benzoyl]amino]pentanedioic acid becomes increasingly important.

In summary, this compound is a prime example of how structural complexity can lead to significant biological activity. As we delve deeper into the world of chemical compounds, the potential of such derivatives continues to inspire scientific inquiry and innovation.