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Trimethoprim

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Identification
Molecular formula
C14H18N4O3
CAS number
738-70-5
IUPAC name
2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone
State
State

Trimethoprim is a solid at room temperature with a crystalline texture.

Melting point (Celsius)
199.00
Melting point (Kelvin)
472.15
Boiling point (Celsius)
409.00
Boiling point (Kelvin)
682.15
General information
Molecular weight
290.34g/mol
Molar mass
290.3350g/mol
Density
1.4600g/cm3
Appearence

Trimethoprim appears as a white or yellowish-white, odorless, crystalline powder. It is practically insoluble in water and slightly soluble in alcohol.

Comment on solubility

Solubility of 2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone

The solubility of the compound 2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone can be influenced by its complex structure and the presence of various functional groups. When evaluating its solubility characteristics, several key factors should be considered:

  • Polarity: The inclusion of hydroxyl (-OH) groups and ether functionalities typically enhances solubility in polar solvents such as water.
  • Hydrophilicity vs. Hydrophobicity: The presence of multiple methoxy groups can introduce hydrophobic characteristics, which may limit solubility in aqueous environments.
  • Interactions: Potential for hydrogen bonding due to hydroxyl groups can improve solvation and contribute positively to solubility in polar solvents.
  • Solvent Choice: This compound may show varying solubility in different organic solvents, and common solvents like DMSO, ethanol, or methanol might be appropriate for dissolution.

In summary, the solubility profile of this compound is likely to be a balance between its polar and nonpolar environments, making it prudent to explore various solvents for effective application. As with many compounds, experimental solubility testing would provide the most accurate assessment of its behavior in solution.

Interesting facts

Interesting Facts About 2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone

This compound, often referred to for its intricate structure and diverse functionality, showcases a unique blend of chemical properties that have garnered the attention of researchers. Here are some interesting insights:

  • Pharmaceutical Relevance: Its complex piperazine ring structure is significant in medicinal chemistry, often seen in various pharmaceutical agents that target specific biological pathways.
  • Polyfunctionality: The presence of multiple methoxy groups along with a hydroxyethoxy group enhances its potential for engaging in a variety of chemical reactions, making it a versatile candidate in drug design and synthesis.
  • Potential Applications: This compound may serve as a lead structure for developing drugs aimed at treating neurological disorders due to its ability to interact with neuroreceptors.
  • Structural Diversity: The combination of the piperazine and phenyl groups contributes to the overall geometric configuration, potentially influencing the pharmacokinetics of the compound.
  • Research Interest: Compounds with such sophisticated structures often attract attention for their unique biological activities, offering opportunities for further study in both academic and industrial settings.

Overall, 2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl}ethanone stands as a remarkable example of how structural complexity in chemistry often correlates with biological activity, prompting ongoing exploration in the realm of therapeutic development.