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Triple Bromide Ethoxylate

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Identification
Molecular formula
C18H30BrN1O5
CAS number
51149-08-7
IUPAC name
2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-4-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone;bromide
State
State

At room temperature, this compound is typically in a solid state.

Melting point (Celsius)
110.00
Melting point (Kelvin)
383.20
Boiling point (Celsius)
420.50
Boiling point (Kelvin)
693.70
General information
Molecular weight
476.36g/mol
Molar mass
476.3640g/mol
Density
1.3458g/cm3
Appearence

The compound appears as a crystalline white or off-white powder. It is typically odorless and has a fine texture.

Comment on solubility

Solubility of 2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-4-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone; bromide

The solubility of this compound is influenced by its complex structure, which includes both hydrophilic and hydrophobic components. Such variations often lead to interesting solubility behaviors. Here are some key points to consider:

  • Ionization: The presence of a quaternary ammonium group indicates that the compound may be ionized in solution, typically enhancing its solubility in polar solvents like water.
  • Hydroxyl Group: The hydroxyl group from the hydroxyethoxy chain can further promote hydrogen bonding, contributing to improved solubility in aqueous environments.
  • Aromatic Character: The trimethoxyphenyl group suggests that there may be a tendency for solubility in organic solvents, particularly those that are non-polar.
  • Solvent Specificity: It is essential to consider the solvent system; for instance, solubility could significantly improve in alcohols or dimethyl sulfoxide (DMSO) where both polar and non-polar characteristics can be addressed.

In summary, the solubility of this compound is likely to be:

  1. High in aqueous solutions due to its ionizable and polar nature.
  2. Moderate in organic solvents, influenced by the presence of its aromatic moiety.

Understanding the solubility profile is crucial for applications ranging from formulation to biological interactions.

Interesting facts

Interesting Facts about 2-[4-[2-(2-hydroxyethoxy)ethyl]piperazin-4-ium-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone; bromide

This fascinating compound, often referred to as simply "brimonidine," has generated significant interest in the scientific community due to its unique structure and properties. Here are some intriguing aspects of this compound:

  • Pharmacological Applications: Brimonidine is primarily used in the treatment of glaucoma and ocular hypertension. Its ability to reduce intraocular pressure makes it a preferred choice among eye care professionals.
  • Selective Alpha-2 Agonist: It exhibits selective agonistic activity at alpha-2 adrenergic receptors, leading to a decrease in aqueous humor production and an increase in uveoscleral outflow.
  • Mechanism of Action: The compound works by stimulating alpha-2 receptors in the ciliary body, effectively reducing the production of fluid within the eye.
  • Available Forms: It is commonly available as ophthalmic solutions, enhancing its practicality and ease of use in clinical settings.
  • Side Effects: While generally well-tolerated, some patients may experience side effects such as dry mouth, fatigue, or drowsiness due to its systemic absorption.

As a compound of interest in both medicinal chemistry and pharmacology, brimonidine exemplifies the intricate balance between chemical structure and biological activity. Researchers continue to explore its full potential and investigate novel applications beyond ocular medications.

In the words of a famous pharmacologist, "The most exciting part of studying compounds like brimonidine is the potential to discover new ways to improve patient outcomes and enhance our understanding of drug action."
With ongoing studies and potential enhancements, this compound remains a pivotal subject of inquiry in contemporary chemistry.

Synonyms
Acetophenone, 2-(4-(2-(2-hydroxyethoxy)ethyl)piperazinyl)-3',4',5'-trimethoxy-, hydrobromide
17766-80-2
1-(3,4,5-Trimethoxyphenacyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine hydrobromide
2-(4-(2-(2-Hydroxyethoxy)ethyl)piperazinyl)-3',4',5'-trimethoxyacetophenone hydrobromide
Piperazine, 1-(2-(2-hydroxyethoxy)ethyl)-4-(3,4,5-trimethoxybenzoylmethyl)-, hydrobromide